Rearrangement and opening of the macrolide of latrunculin B

D. Blasberger*, D. Green, S. Carmely, I. Spector, Y. Kashman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Transformation of latrunculin B (1) into two new 12-membered (4) and 16-membered (3) macrolides and into a 4=substituted-4-thiazolin-2-one (5) all possessing interesting biological activities is reported. The structure of all three new compounds is based mainly on 1D and 2D NMR spectra.

Original languageEnglish
Pages (from-to)459-462
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number4
DOIs
StatePublished - 1987

Funding

FundersFunder number
National Institutes of HealthGM3 2776and
National Institutes of Health
United States-Israel Binational Science Foundation03170
United States-Israel Binational Science Foundation

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