Real-time monitoring of organic reactions with two-dimensional ultrafast TOCSY NMR spectroscopy

Antonio Herrera; Encarnación Fernández-Valle; Roberto Martínez-Álvarez; Dolores Molero; Zulay D. Pardo; Elena Sáez; Maayan Gal

doi:10.1002/anie.200902387

Real-time monitoring of organic reactions with two-dimensional ultrafast TOCSY NMR spectroscopy

Antonio Herrera^*
, Encarnación Fernández-Valle
, Roberto Martínez-Álvarez
, Dolores Molero
, Zulay D. Pardo
, Elena Sáez
, Maayan Gal

^*Corresponding author for this work

Complutense University
Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A quick look reveals all: A two-dimensional ultrafast TOCSY experiment in one scan is presented and used to study the synthesis of pyrimidine from an aliphatic ketone, a nitrile, and Tf ₂O. 525 two-dimensional TOCSY experiments were recorded, and the reactants, intermediates, and products could be monitored (see picture; blue=product; gray, green, and pink=intermediates).

Original language	English
Pages (from-to)	6274-6277
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	34
DOIs	https://doi.org/10.1002/anie.200902387
State	Published - 10 Aug 2009
Externally published	Yes

Keywords

Heterocycles
NMR spectroscopy
Reaction mechanisms
TOCSY

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10.1002/anie.200902387

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abstract = "A quick look reveals all: A two-dimensional ultrafast TOCSY experiment in one scan is presented and used to study the synthesis of pyrimidine from an aliphatic ketone, a nitrile, and Tf 2O. 525 two-dimensional TOCSY experiments were recorded, and the reactants, intermediates, and products could be monitored (see picture; blue=product; gray, green, and pink=intermediates).",

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author = "Antonio Herrera and Encarnaci{\'o}n Fern{\'a}ndez-Valle and Roberto Mart{\'i}nez-{\'A}lvarez and Dolores Molero and Pardo, \{Zulay D.\} and Elena S{\'a}ez and Maayan Gal",

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AU - Herrera, Antonio

AU - Fernández-Valle, Encarnación

AU - Martínez-Álvarez, Roberto

AU - Molero, Dolores

AU - Pardo, Zulay D.

AU - Sáez, Elena

AU - Gal, Maayan

PY - 2009/8/10

Y1 - 2009/8/10

N2 - A quick look reveals all: A two-dimensional ultrafast TOCSY experiment in one scan is presented and used to study the synthesis of pyrimidine from an aliphatic ketone, a nitrile, and Tf 2O. 525 two-dimensional TOCSY experiments were recorded, and the reactants, intermediates, and products could be monitored (see picture; blue=product; gray, green, and pink=intermediates).

AB - A quick look reveals all: A two-dimensional ultrafast TOCSY experiment in one scan is presented and used to study the synthesis of pyrimidine from an aliphatic ketone, a nitrile, and Tf 2O. 525 two-dimensional TOCSY experiments were recorded, and the reactants, intermediates, and products could be monitored (see picture; blue=product; gray, green, and pink=intermediates).

KW - Heterocycles

KW - NMR spectroscopy

KW - Reaction mechanisms

KW - TOCSY

UR - https://www.scopus.com/pages/publications/70349903241

U2 - 10.1002/anie.200902387

DO - 10.1002/anie.200902387

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 34

ER -

Real-time monitoring of organic reactions with two-dimensional ultrafast TOCSY NMR spectroscopy

Abstract

Keywords

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