Real-time monitoring of organic reactions with two-dimensional ultrafast TOCSY NMR spectroscopy

Antonio Herrera*, Encarnación Fernández-Valle, Roberto Martínez-Álvarez, Dolores Molero, Zulay D. Pardo, Elena Sáez, Maayan Gal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A quick look reveals all: A two-dimensional ultrafast TOCSY experiment in one scan is presented and used to study the synthesis of pyrimidine from an aliphatic ketone, a nitrile, and Tf 2O. 525 two-dimensional TOCSY experiments were recorded, and the reactants, intermediates, and products could be monitored (see picture; blue=product; gray, green, and pink=intermediates).

Original languageEnglish
Pages (from-to)6274-6277
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number34
DOIs
StatePublished - 10 Aug 2009
Externally publishedYes

Keywords

  • Heterocycles
  • NMR spectroscopy
  • Reaction mechanisms
  • TOCSY

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