@article{880db686c32c4863861b790f8b7664ec,
title = "RBM28, a protein deficient in ANE syndrome, regulates hair follicle growth via miR-203 and p63",
abstract = "Alopecia-neurological defects-endocrinopathy (ANE) syndrome is a rare inherited hair disorder, which was shown to result from decreased expression of the RNA-binding motif protein 28 (RBM28). In this study, we attempted to delineate the role of RBM28 in hair biology. First, we sought to obtain evidence for the direct involvement of RBM28 in hair growth. When RBM28 was downregulated in human hair follicle (HF) organ cultures, we observed catagen induction and HF growth arrest, indicating that RBM28 is necessary for normal hair growth. We also aimed at identifying molecular targets of RBM28. Given that an RBM28 homologue was recently found to regulate miRNA biogenesis in C. elegans and given the known pivotal importance of miRNAs for proper hair follicle development, we studied global miRNA expression profile in cells knocked down for RBM28. This analysis revealed that RBM28 controls the expression of miR-203. miR-203 was found to regulate in turn TP63, encoding the transcription factor p63, which is critical for hair morphogenesis. In conclusion, RBM28 contributes to HF growth regulation through modulation of miR-203 and p63 activity.",
keywords = "Alopecia, Hair follicle, MiR-203, P63, RBM28",
author = "Emily Warshauer and Liat Samuelov and Ofer Sarig and Dan Vodo and Albrecht Bindereif and Moien Kanaan and Uri Gat and Dana Fuchs-Telem and Noam Shomron and Luba Farberov and Metsada Pasmanik-Chor and Gil Nardini and Eyal Winkler and Benjamin Meilik and Isabelle Petit and Daniel Aberdam and Ralf Paus and Eli Sprecher and Janna Nousbeck",
note = "Publisher Copyright: {\textcopyright} 2015 John Wiley & Sons A/S.",
year = "2015",
month = aug,
day = "1",
doi = "10.1111/exd.12737",
language = "אנגלית",
volume = "24",
pages = "618--622",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "John Wiley and Sons Inc.",
number = "8",
}