Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT

Elise M. Cardinale*, Reut Naim, Simone P. Haller, Ramaris German, Christian Botz-Zapp, Jessica Bezek, David C. Jangraw, Melissa A. Brotman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Identification of behavioral mechanisms underlying psychopathology is essential for the development of novel targeted therapeutics. However, this work relies on rigorous, timeintensive, clinic-based laboratory research, making it difficult to translate research paradigms into tools that can be used by clinicians in the community. The broad adoption of smartphone technology provides a promising opportunity to bridge the gap between the mechanisms identified in the laboratory and the clinical interventions targeting them in the community. The goal of the current study is to develop a developmentally appropriate, engaging, novel mobile application called CALM-IT that probes a narrow biologically informed process, inhibitory control. We aim to leverage the rigorous and robust methods traditionally used in laboratory settings to validate this novel mechanism-driven but easily disseminatable tool that can be used by clinicians to probe inhibitory control in the community. The development of CALM-IT has significant implications for the ability to screen for inhibitory control deficits in the community by both clinicians and researchers. By facilitating assessment of inhibitory control outside of the laboratory setting, researchers could have access to larger and more diverse samples. Additionally, in the clinical setting, CALM-IT represents a novel clinical screening measure that could be used to determine personalized courses of treatment based on the presence of inhibitory control deficits.

Original languageEnglish
Article numbere0252245
JournalPLoS ONE
Issue number6 June
StatePublished - Jun 2021
Externally publishedYes


Dive into the research topics of 'Rationale and validation of a novel mobile application probing motor inhibition: Proof of concept of CALM-IT'. Together they form a unique fingerprint.

Cite this