TY - JOUR
T1 - Rasagiline is neuroprotective in an experimental model of brain ischemia in the rat
AU - Speiser, Z.
AU - Mayk, A.
AU - Litinetsky, L.
AU - Fine, T.
AU - Nyska, A.
AU - Blaugrund, E.
AU - Cohen, S.
PY - 2007/5
Y1 - 2007/5
N2 - The neuroprotective effects of intravenous rasagiline were investigated in a rat model of stroke. Middle cerebral artery (MCA) occlusion was performed in male rats and the short- (neurological severity score [NSS], infarct size), intermediate- (cognition) and long-term (necrotic area) effects were assessed. A bolus (3 mg/kg) of rasagiline followed by a 3-h infusion (3 mg/kg/h), initiated immediately after MCA occlusion, reduced infarct size by 48.6% and NSS by 32.7% relative to saline treatment. Cognitive function, tested in a water maze 2-3 weeks after occlusion, also significantly improved compared with saline-treated controls. Necrotic brain area was 35-50% smaller with rasagiline than with saline following a single bolus dose. The single bolus rasagiline dose was as effective as a rasagiline bolus followed by rasagiline infusion in short-term outcomes. The neuroprotective effect of rasagiline was fully reproducible when administered at 2 h following occlusion but not after 4 h.
AB - The neuroprotective effects of intravenous rasagiline were investigated in a rat model of stroke. Middle cerebral artery (MCA) occlusion was performed in male rats and the short- (neurological severity score [NSS], infarct size), intermediate- (cognition) and long-term (necrotic area) effects were assessed. A bolus (3 mg/kg) of rasagiline followed by a 3-h infusion (3 mg/kg/h), initiated immediately after MCA occlusion, reduced infarct size by 48.6% and NSS by 32.7% relative to saline treatment. Cognitive function, tested in a water maze 2-3 weeks after occlusion, also significantly improved compared with saline-treated controls. Necrotic brain area was 35-50% smaller with rasagiline than with saline following a single bolus dose. The single bolus rasagiline dose was as effective as a rasagiline bolus followed by rasagiline infusion in short-term outcomes. The neuroprotective effect of rasagiline was fully reproducible when administered at 2 h following occlusion but not after 4 h.
KW - Cognition
KW - Histopathological outcome
KW - Infarct volume
KW - Middle cerebral artery occlusion
KW - Neurological severity score
UR - http://www.scopus.com/inward/record.url?scp=34247511535&partnerID=8YFLogxK
U2 - 10.1007/s00702-006-0612-5
DO - 10.1007/s00702-006-0612-5
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AN - SCOPUS:34247511535
SN - 0300-9564
VL - 114
SP - 595
EP - 605
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 5
ER -