Randomized clinical trials in advanced and metastatic colorectal carcinoma

Michael I. D'Angelica*, Margo C. Shoup, Aviram Nissan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The treatment of advanced colorectal cancer has long been a dilemna for clinicians. After many years of therapy limited to 5-fluorouracil (5-FU)-based chemotherapy, a number of new discoveries have significantly advanced this field in the last decade. The advent of irinotecan has given us hope for a second line chemotherapeutic agent and a possible new combination for first line chemotherapy.

Original languageEnglish
Pages (from-to)173-191
Number of pages19
JournalSurgical Oncology Clinics of North America
Issue number1
StatePublished - 2002
Externally publishedYes


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