Radiotherapy in early-stage tongue squamous cell carcinoma with minor adverse features

Orna Katz*, Yuval Nachalon, Ohad Hilly, Thomas Shpitzer, Gideon Bachar, Dror Limon, Aron Popovtzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Treatment for early-stage tongue squamous cell carcinoma (SCC) is usually surgery alone. There is ambiguity regarding the impact of minor adverse features (MAFs) on outcome and the role of postoperative radiotherapy (PORT) in tongue SCC. Methods: A retrospective analysis was performed on 48 patients diagnosed with tongue SCC treated in our center. Patients with MAFs received adjuvant PORT. Disease outcome in patients with MAFs, and the effect of PORT were analyzed using the Kaplan–Meier method and log-rank test. Results: Thirty-one patients had T1 and 17 had T2 disease. PORT was given to 7 patients with MAFs. Mean follow-up time was 70 months. The 2-year overall survival (OS) rate was 86%. Perineural invasion had a significant impact on disease-free survival (DFS; p =.05). There was an improved DFS in patients with MAFs treated with PORT (p =.01). Conclusion: MAFs may have an impact on outcome in tongue SCC, and PORT can improve disease outcome in these patients.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalHead and Neck
Issue number1
StatePublished - 1 Jan 2017


  • minor adverse features
  • oral squamous cell carcinoma
  • perineural invasion
  • postoperative radiation
  • tongue


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