Radioiodine therapy induced sialadenitis versus chronic idiopathic sialadenitis—Presentation and outcomes

Hanna Gilat*, Igor Vainer, Gal Avishai, Shiri L. Maymon, Uri Alkan, Roy Hod, Eyal Robenshtock, Sivan Friedman, Thomas Shpitzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: This study explores the unique characters of high dose radioactive iodine (RAI) induced chronic sialadenitis. Methods: A retrospective study of patients having received salivary endoscopy and followed in our outpatient clinic. Results: A total of 100 patients met the inclusion criteria, 75 were diagnosed with chronic idiopathic sialoadenitis and 25 with radio-iodine induced sialoadenitis (RIS). The main complaint in both groups was swelling of the parotid gland. Pain, dysphagia, and xerostomia were observed considerably more in the RIS group. During sialo-endoscopy, fibrosis of the Stensen's duct was more common in the RIS group (p = 0.003). RIS patients group generally managed better with interventional endoscopic treatment alone (80% vs. 46%). Conclusion: RIS patients have distinct clinical characteristics. There may be a collateral muscular damage to the masticatory muscles. Fibrosis and parenchymal damage are major findings during sialendoscopy. Sialendoscopy is a safe and efficient treatment for RAI induced sialadenitis.

Original languageEnglish
Pages (from-to)2724-2730
Number of pages7
JournalHead and Neck
Issue number9
StatePublished - Sep 2021


  • chronic sialadenitis
  • endoscopy
  • radiation myopathy
  • radioactive iodine
  • salivary


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