Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: Safety and feasibility

Pasquale Santangeli, Luigi Di Biase, Dhanunjay Lakkireddy, J. David Burkhardt, Jayasree Pillarisetti, Yoav Michowitz, Javier E. Sanchez, Rodney Horton, Prasant Mohanty, G. Joseph Gallinghouse, Antonio Dello Russo, Michela Casella, Gemma Pelargonio, Pietro Santarelli, Atul Verma, Calambur Narasimhan, Kalyanam Shivkumar, Andrea Natale*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Background: Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective: The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods: Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results: Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3% ± 9.8%. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73%. No major complication was observed during and after the procedures in all patients. Conclusion: Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate.

Original languageEnglish
Pages (from-to)1036-1042
Number of pages7
JournalHeart Rhythm
Issue number8
StatePublished - 2010
Externally publishedYes


  • Catheter ablation
  • Hypertrophic cardiomyopathy
  • Outcomes
  • Ventricular tachycardia


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