@article{9ca2ddd72812406baeb524d3fb8efe3b,
title = "Radiation Dose-Volume Effects in the Heart",
abstract = "The literature is reviewed to identify the main clinical and dose-volume predictors for acute and late radiation-induced heart disease. A clear quantitative dose and/or volume dependence for most cardiac toxicity has not yet been shown, primarily because of the scarcity of the data. Several clinical factors, such as age, comorbidities and doxorubicin use, appear to increase the risk of injury. The existing dose-volume data is presented, as well as suggestions for future investigations to better define radiation-induced cardiac injury.",
keywords = "Breast cancer, Dose-volume predictors, Esophagus cancer, Lymphoma, NTCP, Radiation heart disease",
author = "Giovanna Gagliardi and Constine, {Louis S.} and Vitali Moiseenko and Candace Correa and Pierce, {Lori J.} and Allen, {Aaron M.} and Marks, {Lawrence B.}",
note = "Funding Information: Supported in part by grants from the NIH ( CA69579 ) and the Lance Armstrong Foundation (LBM).",
year = "2010",
month = mar,
day = "1",
doi = "10.1016/j.ijrobp.2009.04.093",
language = "אנגלית",
volume = "76",
pages = "S77--S85",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "3 SUPPL.",
}
