Radiation Dose-Volume Effects in the Heart

Giovanna Gagliardi*, Louis S. Constine, Vitali Moiseenko, Candace Correa, Lori J. Pierce, Aaron M. Allen, Lawrence B. Marks

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The literature is reviewed to identify the main clinical and dose-volume predictors for acute and late radiation-induced heart disease. A clear quantitative dose and/or volume dependence for most cardiac toxicity has not yet been shown, primarily because of the scarcity of the data. Several clinical factors, such as age, comorbidities and doxorubicin use, appear to increase the risk of injury. The existing dose-volume data is presented, as well as suggestions for future investigations to better define radiation-induced cardiac injury.

Original languageEnglish
Pages (from-to)S77-S85
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number3 SUPPL.
StatePublished - 1 Mar 2010
Externally publishedYes


FundersFunder number
National Institutes of Health
National Cancer InstituteR29CA069579
Lance Armstrong Foundation


    • Breast cancer
    • Dose-volume predictors
    • Esophagus cancer
    • Lymphoma
    • NTCP
    • Radiation heart disease


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