RACK1 has the nerve to act: Structure meets function in the nervous system

Ella H. Sklan, Erez Podoly, Hermona Soreq*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The receptor for activated protein kinase C 1 (RACK1) is an intracellular adaptor protein. Accumulating evidence attributes to this member of the tryptophan-aspartate (WD) repeat family the role of regulating several major nervous system pathways. Structurally, RACK1 is a seven-bladed-β-propeller, interacting with diverse proteins having distinct structural folds. When bound to the IP3 receptor, RACK1 regulates intracellular Ca2+ levels, potentially contributing to processes such as learning, memory and synaptic plasticity. By binding to the NMDA receptor, it dictates neuronal excitation and sensitivity to ethanol. When bound to the stress-induced acetylcholinesterase variant AChE-R, RACK1 is implicated in stress responses and behavior, compatible with reports of RACK1 modulations in brain ageing and in various neurodegenerative diseases. This review sheds new light on both the virtues and the variety of neuronal RACK1 interactions and their physiological consequences.

Original languageEnglish
Pages (from-to)117-134
Number of pages18
JournalProgress in Neurobiology
Issue number2
StatePublished - Feb 2006
Externally publishedYes


FundersFunder number
European CommissionLSHM-CT-2003-503330
Israel Science Foundation618-02


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