TY - JOUR
T1 - Quinpirole induces compulsive checking behavior in rats
T2 - A potential animal model of obsessive-compulsive disorder (OCD)
AU - Szechtman, Henry
AU - Sulis, William
AU - Eilam, David
PY - 1998
Y1 - 1998
N2 - Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly x 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with single small objects in 4 of 25 locales, quinpirole rats revisited two places/objects excessively often and rapidly, compared with other locations in the environment or saline controls. They performed a ritual-like set of behavioral acts at these two places/objects and stopped in relatively few locales before returning to the preferred places/objects. Finally, they shifted their behavior to a new location when the object was moved there. Clomipramine (10 mg/kg, daily) postponed but did not prevent the development of the quinpirole effect. Quinpirole-induced compulsive checking may be an exaggeration of normal checking of home site in rats. Results suggest an animal model of obsessive- compulsive disorder and a role for dopamine in this disorder.
AB - Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly x 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with single small objects in 4 of 25 locales, quinpirole rats revisited two places/objects excessively often and rapidly, compared with other locations in the environment or saline controls. They performed a ritual-like set of behavioral acts at these two places/objects and stopped in relatively few locales before returning to the preferred places/objects. Finally, they shifted their behavior to a new location when the object was moved there. Clomipramine (10 mg/kg, daily) postponed but did not prevent the development of the quinpirole effect. Quinpirole-induced compulsive checking may be an exaggeration of normal checking of home site in rats. Results suggest an animal model of obsessive- compulsive disorder and a role for dopamine in this disorder.
UR - http://www.scopus.com/inward/record.url?scp=0032441547&partnerID=8YFLogxK
U2 - 10.1037/0735-7044.112.6.1475
DO - 10.1037/0735-7044.112.6.1475
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AN - SCOPUS:0032441547
SN - 0735-7044
VL - 112
SP - 1475
EP - 1485
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 6
ER -