Quinacrine inhibits oxygen radicals release from human alveolar macrophages

David Struhar*, S. Kivity, Marcel Topilsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the effect of quinacrine, an anti-malarial drug which inhibits phospholipase A2, on phorbol myristate acetate (PMA) stimulated alveolar macrophage oxygen radical secretion. This drug suppressed 30% of radicals release, which was 70% of the amount inhibited by superoxide dismutase, a specific inhibitor of oxygen radicals. In addition, this reduction was at the same magnitude as dexamethasone. This and previous results on other inflammatory cells support the assumption that quinacrine may have a beneficial effect on bronchial asthma.

Original languageEnglish
Pages (from-to)275-277
Number of pages3
JournalInternational Journal of Immunopharmacology
Volume14
Issue number2
DOIs
StatePublished - Feb 1992
Externally publishedYes

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