TY - JOUR
T1 - Quaternary Ammonium Silica Nanoparticles for Antimicrobial Implantable Medical Devices
T2 - An In Vitro Study
AU - Weiss, Eitam
AU - Berl, Ariel
AU - Shir-az, Ofir
AU - Bilal, Biader Samih
AU - Weiss, Ervin I.
AU - Paitan, Yossi
AU - Zaltsman, Natan
AU - Golberg, Alexander
AU - Shalom, Avshalom
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/12
Y1 - 2024/12
N2 - Biofilm formation on prostheses and implanted devices can lead to serious complications and increased healthcare expenditures. Once formed, biofilm management is difficult and may involve a long course of antibiotics, additional surgery, and, occasionally, implant removal. This study evaluated the antibacterial properties of medical-grade silicone samples integrated with novel, non-leaching, antibacterial, quaternary ammonium silica (QASi) particles. Our collaborators (Nobio, Israel) prepared silicone sheets integrated with antibacterial QASi nanoparticles. Samples containing 0.5%, 0.75%, and 1%, QASi particles were evaluated for antibacterial properties against S. epidermidis, S. aureus, methicillin-resistant S. aureus (MRSA), E. faecalis, and P. aeruginosa using the direct contact test. The tested silicone samples integrated with QASi particles showed no bacterial growth, while growth was observed in control silicone samples without QASi. In addition, the agar diffusion test, used to evaluate the leaching of antibacterial components, exhibited no inhibition zone around the samples indicating that the QASi particles do not leach into surrounding milieu. The QASi nanoparticles exhibited very potent antibacterial surface properties, killing all viable bacteria placed on their surface. Incorporating QASi nanoparticle technology into medical products during production has the potential to create an antimicrobial surface that prevents microbial colonization and biofilm formation.
AB - Biofilm formation on prostheses and implanted devices can lead to serious complications and increased healthcare expenditures. Once formed, biofilm management is difficult and may involve a long course of antibiotics, additional surgery, and, occasionally, implant removal. This study evaluated the antibacterial properties of medical-grade silicone samples integrated with novel, non-leaching, antibacterial, quaternary ammonium silica (QASi) particles. Our collaborators (Nobio, Israel) prepared silicone sheets integrated with antibacterial QASi nanoparticles. Samples containing 0.5%, 0.75%, and 1%, QASi particles were evaluated for antibacterial properties against S. epidermidis, S. aureus, methicillin-resistant S. aureus (MRSA), E. faecalis, and P. aeruginosa using the direct contact test. The tested silicone samples integrated with QASi particles showed no bacterial growth, while growth was observed in control silicone samples without QASi. In addition, the agar diffusion test, used to evaluate the leaching of antibacterial components, exhibited no inhibition zone around the samples indicating that the QASi particles do not leach into surrounding milieu. The QASi nanoparticles exhibited very potent antibacterial surface properties, killing all viable bacteria placed on their surface. Incorporating QASi nanoparticle technology into medical products during production has the potential to create an antimicrobial surface that prevents microbial colonization and biofilm formation.
KW - antibacterial technology
KW - antimicrobial QASi particles
KW - biofilm
KW - nanoparticles
KW - silicone
UR - http://www.scopus.com/inward/record.url?scp=85213381641&partnerID=8YFLogxK
U2 - 10.3390/life14121654
DO - 10.3390/life14121654
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C2 - 39768361
AN - SCOPUS:85213381641
SN - 2075-1729
VL - 14
JO - Life
JF - Life
IS - 12
M1 - 1654
ER -
