Quantum image scanning microscopy: Concept and considerations towards applicability

Ron Tenne, Uri Rossman, Batel Rephael, Yonatan Israel, Alexander Krupinski-Ptaszek, Radek Lapkiewicz, Yaron Silberberg, Dan Oron

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Technological advancements in the creation, manipulation and detection of quantum states of light have motivated the application of such states to overcome classical limits in sensing and imaging. In particular, there has been a surge of recent interest in super-resolution imaging based on principles of quantum optics. However, the application of such schemes for practical imaging of biological samples is demanding in terms of signal-to-noise ratio, speed of acquisition and robustness with respect to sample labeling. Here, we re-introduce the concept of quantum image scanning microscopy (Q-ISM), a super-resolution method that enhances the classical image scanning microscopy (ISM) method by measuring photon correlations. Q-ISM was already utilized to achieve super-resolved images of a biological sample labeled with fluorescent nanoscrystals whose contrast is based entirely on a quantum optical phenomenon, photon antibunching. We present here an experimental demonstration of the method and discuss with further details its prospects for application in life science microscopy.

Original languageEnglish
Title of host publicationOptical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology
EditorsJacob Scheuer, Selim M. Shahriar
ISBN (Electronic)9781510625105
StatePublished - 2019
Externally publishedYes
EventOptical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology 2019 - San Francisco, United States
Duration: 2 Feb 20197 Feb 2019

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceOptical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology 2019
Country/TerritoryUnited States
CitySan Francisco


  • Image scanning microscopy
  • Photon antibunching
  • Quantum imaging
  • Super-resolution microscopy


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