TY - GEN
T1 - Quantum image scanning microscopy
T2 - Optical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology 2019
AU - Tenne, Ron
AU - Rossman, Uri
AU - Rephael, Batel
AU - Israel, Yonatan
AU - Krupinski-Ptaszek, Alexander
AU - Lapkiewicz, Radek
AU - Silberberg, Yaron
AU - Oron, Dan
N1 - Publisher Copyright:
© 2019 SPIE CCC.
PY - 2019
Y1 - 2019
N2 - Technological advancements in the creation, manipulation and detection of quantum states of light have motivated the application of such states to overcome classical limits in sensing and imaging. In particular, there has been a surge of recent interest in super-resolution imaging based on principles of quantum optics. However, the application of such schemes for practical imaging of biological samples is demanding in terms of signal-to-noise ratio, speed of acquisition and robustness with respect to sample labeling. Here, we re-introduce the concept of quantum image scanning microscopy (Q-ISM), a super-resolution method that enhances the classical image scanning microscopy (ISM) method by measuring photon correlations. Q-ISM was already utilized to achieve super-resolved images of a biological sample labeled with fluorescent nanoscrystals whose contrast is based entirely on a quantum optical phenomenon, photon antibunching. We present here an experimental demonstration of the method and discuss with further details its prospects for application in life science microscopy.
AB - Technological advancements in the creation, manipulation and detection of quantum states of light have motivated the application of such states to overcome classical limits in sensing and imaging. In particular, there has been a surge of recent interest in super-resolution imaging based on principles of quantum optics. However, the application of such schemes for practical imaging of biological samples is demanding in terms of signal-to-noise ratio, speed of acquisition and robustness with respect to sample labeling. Here, we re-introduce the concept of quantum image scanning microscopy (Q-ISM), a super-resolution method that enhances the classical image scanning microscopy (ISM) method by measuring photon correlations. Q-ISM was already utilized to achieve super-resolved images of a biological sample labeled with fluorescent nanoscrystals whose contrast is based entirely on a quantum optical phenomenon, photon antibunching. We present here an experimental demonstration of the method and discuss with further details its prospects for application in life science microscopy.
KW - Image scanning microscopy
KW - Photon antibunching
KW - Quantum imaging
KW - Super-resolution microscopy
UR - http://www.scopus.com/inward/record.url?scp=85064866175&partnerID=8YFLogxK
U2 - 10.1117/12.2514459
DO - 10.1117/12.2514459
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AN - SCOPUS:85064866175
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Optical, Opto-Atomic, and Entanglement-Enhanced Precision Metrology
A2 - Scheuer, Jacob
A2 - Shahriar, Selim M.
PB - SPIE
Y2 - 2 February 2019 through 7 February 2019
ER -