Quantitative trait loci for resistance to heligmosomoides bakeri and associated immunological and pathological traits in mice: Comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

J. M. Behnke; D. M. Menge; S. Nagda; H. Noyes; F. A. Iraqi; S. J. Kemp; R. J.M. Mugambi; R. L. Baker; D. Wakelin; J. P. Gibson

doi:10.1017/S0031182009991028

Quantitative trait loci for resistance to heligmosomoides bakeri and associated immunological and pathological traits in mice: Comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

J. M. Behnke, D. M. Menge, S. Nagda, H. Noyes, F. A. Iraqi, S. J. Kemp, R. J.M. Mugambi, R. L. Baker, D. Wakelin, J. P. Gibson

Clinical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.

Original language	English
Pages (from-to)	311-320
Number of pages	10
Journal	Parasitology
Volume	137
Issue number	2
DOIs	https://doi.org/10.1017/S0031182009991028
State	Published - Feb 2010

Keywords

Antibody
Granulomatous response
Heligmosomoides bakeri
Heligmosomoides polygyrus
IgG1
MCPT1
Mcpt1
Nematodes
QTL
Resistance

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Behnke, J. M., Menge, D. M., Nagda, S., Noyes, H., Iraqi, F. A., Kemp, S. J., Mugambi, R. J. M., Baker, R. L., Wakelin, D., & Gibson, J. P. (2010). Quantitative trait loci for resistance to heligmosomoides bakeri and associated immunological and pathological traits in mice: Comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice. Parasitology, 137(2), 311-320. https://doi.org/10.1017/S0031182009991028

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title = "Quantitative trait loci for resistance to heligmosomoides bakeri and associated immunological and pathological traits in mice: Comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice",

abstract = "A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.",

keywords = "Antibody, Granulomatous response, Heligmosomoides bakeri, Heligmosomoides polygyrus, IgG1, MCPT1, Mcpt1, Nematodes, QTL, Resistance",

author = "Behnke, {J. M.} and Menge, {D. M.} and S. Nagda and H. Noyes and Iraqi, {F. A.} and Kemp, {S. J.} and Mugambi, {R. J.M.} and Baker, {R. L.} and D. Wakelin and Gibson, {J. P.}",

year = "2010",

month = feb,

doi = "10.1017/S0031182009991028",

language = "אנגלית",

volume = "137",

pages = "311--320",

journal = "Parasitology",

issn = "0031-1820",

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Behnke, JM, Menge, DM, Nagda, S, Noyes, H, Iraqi, FA, Kemp, SJ, Mugambi, RJM, Baker, RL, Wakelin, D & Gibson, JP 2010, 'Quantitative trait loci for resistance to heligmosomoides bakeri and associated immunological and pathological traits in mice: Comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice', Parasitology, vol. 137, no. 2, pp. 311-320. https://doi.org/10.1017/S0031182009991028

Quantitative trait loci for resistance to heligmosomoides bakeri and associated immunological and pathological traits in mice: Comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice. / Behnke, J. M.; Menge, D. M.; Nagda, S. et al.
In: Parasitology, Vol. 137, No. 2, 02.2010, p. 311-320.

Research output: Contribution to journal › Article › peer-review

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T1 - Quantitative trait loci for resistance to heligmosomoides bakeri and associated immunological and pathological traits in mice

T2 - Comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

AU - Behnke, J. M.

AU - Menge, D. M.

AU - Nagda, S.

AU - Noyes, H.

AU - Iraqi, F. A.

AU - Kemp, S. J.

AU - Mugambi, R. J.M.

AU - Baker, R. L.

AU - Wakelin, D.

AU - Gibson, J. P.

PY - 2010/2

Y1 - 2010/2

N2 - A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.

AB - A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.

KW - Antibody

KW - Granulomatous response

KW - Heligmosomoides bakeri

KW - Heligmosomoides polygyrus

KW - IgG1

KW - MCPT1

KW - Mcpt1

KW - Nematodes

KW - QTL

KW - Resistance

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DO - 10.1017/S0031182009991028

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SN - 0031-1820

VL - 137

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JO - Parasitology

JF - Parasitology

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ER -

Quantitative trait loci for resistance to heligmosomoides bakeri and associated immunological and pathological traits in mice: Comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

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Keywords

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