Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications

Ilan Bank*, Victoria Marcu-Malina

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Human γδ T cells, which play innate and adaptive, protective as well as destructive, roles in the immune response, were discovered in 1986, but the clinical significance of alterations of the levels of these cells in the peripheral blood in human diseases has not been comprehensively reviewed. Here, we review patterns of easily measurable changes of this subset of T cells in peripheral blood from relevant publications in PubMed and their correlations with specific disease categories, specific diagnoses within disease categories, and prognostic outcomes. These collective data suggest that enumeration of γδ T cells and their subsets in the peripheral blood of patients could be a useful tool to evaluate diagnosis and prognosis in the clinical setting.

Original languageEnglish
Pages (from-to)311-333
Number of pages23
JournalClinical Reviews in Allergy and Immunology
Volume47
Issue number3
DOIs
StatePublished - 21 Nov 2014
Externally publishedYes

Keywords

  • Differential diagnosis
  • Gamma delta T cells
  • Gammadelta T cells
  • Human diseases
  • Peripheral blood gammadelta T cells
  • Prognosis

Fingerprint

Dive into the research topics of 'Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications'. Together they form a unique fingerprint.

Cite this