Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications

Ilan Bank; Victoria Marcu-Malina

doi:10.1007/s12016-013-8391-x

Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications

Ilan Bank^*, Victoria Marcu-Malina

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Human γδ T cells, which play innate and adaptive, protective as well as destructive, roles in the immune response, were discovered in 1986, but the clinical significance of alterations of the levels of these cells in the peripheral blood in human diseases has not been comprehensively reviewed. Here, we review patterns of easily measurable changes of this subset of T cells in peripheral blood from relevant publications in PubMed and their correlations with specific disease categories, specific diagnoses within disease categories, and prognostic outcomes. These collective data suggest that enumeration of γδ T cells and their subsets in the peripheral blood of patients could be a useful tool to evaluate diagnosis and prognosis in the clinical setting.

Original language	English
Pages (from-to)	311-333
Number of pages	23
Journal	Clinical Reviews in Allergy and Immunology
Volume	47
Issue number	3
DOIs	https://doi.org/10.1007/s12016-013-8391-x
State	Published - 21 Nov 2014
Externally published	Yes

Keywords

Differential diagnosis
Gamma delta T cells
Gammadelta T cells
Human diseases
Peripheral blood gammadelta T cells
Prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s12016-013-8391-x

Cite this

@article{aa3d2270e9c74a77b121730a40c900f2,

title = "Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications",

abstract = "Human γδ T cells, which play innate and adaptive, protective as well as destructive, roles in the immune response, were discovered in 1986, but the clinical significance of alterations of the levels of these cells in the peripheral blood in human diseases has not been comprehensively reviewed. Here, we review patterns of easily measurable changes of this subset of T cells in peripheral blood from relevant publications in PubMed and their correlations with specific disease categories, specific diagnoses within disease categories, and prognostic outcomes. These collective data suggest that enumeration of γδ T cells and their subsets in the peripheral blood of patients could be a useful tool to evaluate diagnosis and prognosis in the clinical setting.",

keywords = "Differential diagnosis, Gamma delta T cells, Gammadelta T cells, Human diseases, Peripheral blood gammadelta T cells, Prognosis",

author = "Ilan Bank and Victoria Marcu-Malina",

note = "Publisher Copyright: {\textcopyright} 2013, Springer Science+Business Media New York.",

year = "2014",

month = nov,

day = "21",

doi = "10.1007/s12016-013-8391-x",

language = "אנגלית",

volume = "47",

pages = "311--333",

journal = "Clinical Reviews in Allergy and Immunology",

issn = "1080-0549",

publisher = "Humana Press",

number = "3",

}

TY - JOUR

T1 - Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications

AU - Bank, Ilan

AU - Marcu-Malina, Victoria

PY - 2014/11/21

Y1 - 2014/11/21

N2 - Human γδ T cells, which play innate and adaptive, protective as well as destructive, roles in the immune response, were discovered in 1986, but the clinical significance of alterations of the levels of these cells in the peripheral blood in human diseases has not been comprehensively reviewed. Here, we review patterns of easily measurable changes of this subset of T cells in peripheral blood from relevant publications in PubMed and their correlations with specific disease categories, specific diagnoses within disease categories, and prognostic outcomes. These collective data suggest that enumeration of γδ T cells and their subsets in the peripheral blood of patients could be a useful tool to evaluate diagnosis and prognosis in the clinical setting.

AB - Human γδ T cells, which play innate and adaptive, protective as well as destructive, roles in the immune response, were discovered in 1986, but the clinical significance of alterations of the levels of these cells in the peripheral blood in human diseases has not been comprehensively reviewed. Here, we review patterns of easily measurable changes of this subset of T cells in peripheral blood from relevant publications in PubMed and their correlations with specific disease categories, specific diagnoses within disease categories, and prognostic outcomes. These collective data suggest that enumeration of γδ T cells and their subsets in the peripheral blood of patients could be a useful tool to evaluate diagnosis and prognosis in the clinical setting.

KW - Differential diagnosis

KW - Gamma delta T cells

KW - Gammadelta T cells

KW - Human diseases

KW - Peripheral blood gammadelta T cells

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=84902090448&partnerID=8YFLogxK

U2 - 10.1007/s12016-013-8391-x

DO - 10.1007/s12016-013-8391-x

M3 - סקירה

C2 - 24126758

AN - SCOPUS:84902090448

VL - 47

SP - 311

EP - 333

JO - Clinical Reviews in Allergy and Immunology

JF - Clinical Reviews in Allergy and Immunology

SN - 1080-0549

IS - 3

ER -

Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this