Quantitative imaging biomarkers for dural sinus patterns in idiopathic intracranial hypertension

Dinah Zur, Reut Anconina, Anat Kesler, Svetlana Lublinsky, Ronen Toledano, Ilan Shelef*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objective: To quantitatively characterize transverse dural sinuses (TS) on magnetic resonance venography (MRV) in patients with idiopathic intracranial hypertension (IIH), compared to healthy controls, using a computer assisted detection (CAD) method. Materials and Methods: We retrospectively analyzed MRV studies of 38 IIH patients and 30 controls, matched by age and gender. Data analysis was performed using a specially developed Matlab algorithm for vessel cross-sectional analysis. The cross-sectional area and shape measurements were evaluated in patients and controls. Results: Mean, minimal, and maximal cross-sectional areas as well as volumetric parameters of the right and left transverse sinuses were significantly smaller in IIH patients than in controls (p <.005 for all). Idiopathic intracranial hypertension patients showed a narrowed segment in both TS, clustering near the junction with the sigmoid sinus. In 36% (right TS) and 43% (left TS), the stenosis extended to >50% of the entire length of the TS, i.e. the TS was hypoplastic. Narrower vessels tended to have a more triangular shape than did wider vessels. Conclusion: Using CAD we precisely quantified TS stenosis and its severity in IIH patients by cross-sectional and volumetric analysis. This method can be used as an exact tool for investigating mechanisms of IIH development and response to treatment.

Original languageEnglish
Article numbere00613
JournalBrain and Behavior
Issue number2
StatePublished - 1 Feb 2017


FundersFunder number
Israel Science Foundation
Tel Aviv University


    • MRI
    • idiopathic intracranial hypertension
    • neuro-ophthalmology


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