Quantification of in vitro wear of a synthetic meniscus implant using gravimetric and micro-CT measurements

Jonathan J. Elsner, Maoz Shemesh, Adaya Shefy-Peleg, Yankel Gabet, Eyal Zylberberg, Eran Linder-Ganz

Research output: Contribution to journalArticlepeer-review


A synthetic meniscus implant was recently developed for the treatment of patients with mild to moderate osteoarthritis with knee pain associated with medial joint overload. The implant is distinctively different from most orthopedic implants in its pliable construction, and non-anchored design, which enables implantation through a mini-arthrotomy without disruption to the bone, cartilage, and ligaments. Due to these features, it is important to show that the material and design can withstand knee joint conditions. This study evaluated the long-term performance of this device by simulating loading for a total of 5 million gait cycles (Mc), corresponding to approximately five years of service in-vivo. All five implants remained in good condition and did not dislodge from the joint space during the simulation. Mild abrasion was detected by electron microscopy, but μ-CT scans of the implants confirmed that the damage was confined to the superficial surfaces. The average gravimetric wear rate was 14.5mg/Mc, whereas volumetric changes in reconstructed μ-CT scans point to an average wear rate of 15.76mm3/Mc (18.8mg/Mc). Particles isolated from the lubricant had average diameter of 15μm. The wear performance of this polycarbonate-urethane meniscus implant concept under ISO-14243 loading conditions is encouraging.

Original languageEnglish
Pages (from-to)310-320
Number of pages11
JournalJournal of the Mechanical Behavior of Biomedical Materials
StatePublished - 1 Sep 2015


  • Fatigue
  • Meniscectomy
  • Polycarbonate-urethane
  • Prosthesis
  • Simulator


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