Quality of life of patients with thyroid eye disease: 3-year follow-up in a multidisciplinary clinic in Israel

Ofira Zloto*, Oded Sagiv, Ayelet Priel, Tali Cukierman-Yaffe, Amir Tirosh, Nancy Agmon-Levin, Shiran Madgar, Tal Serlin, Guy Ben Simon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Changes in the quality of life (QOL) of patients with thyroid eye disease (TED) were examined during a 3-year follow-up in a multidisciplinary eye clinic, and factors that may improve QOL were identified. Methods: A retrospective review of medical records of all patients who attended the TED clinic at Sheba Medical Center, Israel, from May 2016 to May 2019 was performed. The retrieved data included demographics, comprehensive ophthalmic examination findings, clinical activity scores (CAS), laboratory test results, and QOL assessments by the Graves’ Orbitopathy QOL (GO-QOL) questionnaire. Results: One hundred thirty-two TED clinic patients were examined. Thirty patients (22.72%) received medical treatment consisting of steroids according to the European Group on Graves’ Orbitopathy (EUGOGO) protocol, high-dose steroids, or immunosuppressive drugs. Twenty-eight patients (21.21%) underwent surgical rehabilitation (decompression, strabismus, or eyelid surgery). There was a significant increase in total QOL score after steroid treatment according to the EUGOGO protocol, after decompression surgery, and after strabismus surgery compared to pre-treatment total QOL (p=0.04, p=0.021, and p=0.042, respectively, matched pairs). In addition, there were significant positive correlations between the changes in the total QOL score and the change in thyroid-stimulating immunoglobulin (TSI) as well as the change in CAS among the patients who underwent medical and surgical interventions. Conclusions: QOL improved significantly after medical/surgical treatments. A change in the CAS and in the TSI may also correlate with change in QOL. Periodic evaluation of TED patients’ QOL is recommended for enhanced and more comprehensive management. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)2009-2015
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number7
StatePublished - Jul 2021


  • European Group on Graves’ Orbitopathy
  • Graves’ orbitopathy
  • Quality of life
  • Thyroid eye disease


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