Quality of life following lobectomy versus total thyroidectomy is significantly related to hypothyroidism

Dan Yaniv*, Igor Vainer, Ido Amir, Eyal Robenshtok, Dania Hirsch, Torquil Watt, Ohad Hilly, Yotam Shkedy, Thomas Shpitzer, Gideon Bachar, Raphael Feinmesser, Aviram Mizrachi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: The aim of the present study was to investigate the differences in quality of life (QOL) following complete or partial thyroidectomy and with regard to thyroid hormone replacement (LT4) therapy. Study Design: Patients who underwent thyroidectomy were asked to complete the validated thyroid-specific ThyPRO QOL questionnaire at least 6 months following surgery. Setting: Tertiary medical center. Methods: Thyroid specific QOL questionnaire analysis. Results: A total of 190 patients completed the ThyPRO questionnaire. Of them 89 patients had complete thyroidectomy and 101 patients had unilateral thyroid lobectomy. The total thyroidectomy group had significantly worse overall QOL self-assessment score than the lobectomy patients (p < 0.0001). Patients receiving LT4 therapy regardless of the extent of surgery, reported worse QOL compared to patients not receiving LT4. Conclusions: Quality of life following thyroid surgery is significantly related to hypothyroidism and the requirement for LT4 therapy, rather to the extent of surgery. The best QOL was reported in patients treated with lobectomy who did not require LT4 therapy.

Original languageEnglish
Pages (from-to)640-648
Number of pages9
JournalJournal of Surgical Oncology
Issue number4
StatePublished - 15 Sep 2022


  • PRO
  • QOL
  • TSH
  • hypothyroidism
  • thyroidectomy


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