TY - JOUR
T1 - Quality of life following epilepsy surgery for children with tuberous sclerosis complex
AU - Roth, Jonathan
AU - Olasunkanmi, Adeolu
AU - MacAllister, William S.
AU - Weil, Emily
AU - Uy, Catherine C.
AU - Devinsky, Orrin
AU - Weiner, Howard L.
PY - 2011/3
Y1 - 2011/3
N2 - Parents of children with tuberous sclerosis complex who underwent multistage resections for treatment of refractory seizures were offered a telephone questionnaire regarding quality of life (QOL) of child and family since surgery. Of 53 families, 39 responded. Age at epilepsy onset was birth to 3. months. Average duration of epilepsy before the first surgery was 5.1. years, and average age at surgery was 5.8. The average follow-up was 3.9. Seventy-seven percent had a > 90% reduction in disabling seizures. In all outcome categories, 46-85% had at least a moderate improvement in QOL. There was a significant correlation between QOL variables and Engel outcome class. Despite the potential burden posed by the aggressive surgical approach, including multiple surgeries and long hospitalization periods, 94% of parents would choose the same course once again. We conclude that aggressive surgical treatment of tuberous sclerosis complex-related refractory seizures is associated with significant control of epilepsy as well as improved QOL for the patient and family.
AB - Parents of children with tuberous sclerosis complex who underwent multistage resections for treatment of refractory seizures were offered a telephone questionnaire regarding quality of life (QOL) of child and family since surgery. Of 53 families, 39 responded. Age at epilepsy onset was birth to 3. months. Average duration of epilepsy before the first surgery was 5.1. years, and average age at surgery was 5.8. The average follow-up was 3.9. Seventy-seven percent had a > 90% reduction in disabling seizures. In all outcome categories, 46-85% had at least a moderate improvement in QOL. There was a significant correlation between QOL variables and Engel outcome class. Despite the potential burden posed by the aggressive surgical approach, including multiple surgeries and long hospitalization periods, 94% of parents would choose the same course once again. We conclude that aggressive surgical treatment of tuberous sclerosis complex-related refractory seizures is associated with significant control of epilepsy as well as improved QOL for the patient and family.
KW - Multistage surgeries
KW - Quality of life
KW - Refractory epilepsy
KW - Tuberous sclerosis
UR - http://www.scopus.com/inward/record.url?scp=79952734851&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2010.11.003
DO - 10.1016/j.yebeh.2010.11.003
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C2 - 21288778
AN - SCOPUS:79952734851
SN - 1525-5050
VL - 20
SP - 561
EP - 565
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
IS - 3
ER -