Mitochondria are essential components of the eukaryotic cell, containing the machinery for efficient ATP production by oxidative phosphorylation and other metabolic processes. However, a side effect of these reactions is the generation of reactive oxygen species (ROS), which are deleterious to the integrity and functioning of mitochondria and to the cells which harbor them. Fortunately, cells possess a number of mechanisms to counter ROS damage in mitochondria, including repair, bypass reactions, and the degradation of damaged proteins and organelles. This final process occurs by utilizing the autophagic machinery to target damaged mitochondria for vacuolar degradation, and is termed mitophagy. This review discusses different mechanisms of mitochondrial quality control in yeast cells, with an emphasis on mitophagy.
|Title of host publication||Mitophagy|
|Number of pages||17|
|State||Published - 25 Jul 2014|
- Mitochondrial dynamics
- Mitochondrial quality control
- Mitophagy research