QT dispersion in amyloidosis due to familial Mediterranean fever

Udi Nussinovitch, Naomi Nussinovitch, Moshe Nussinovitch, Benjamin Volovitz, Olga Feld, Ilan Ben-Zvi, Avi Livneh

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac amyloid deposition in FMF may cause increased QT dispersion (QTd), a marker for cardiac arrhythmias. The aim of this study was to further evaluate repolarization dispersion in familial Mediterranean fever (FMF) with amyloidosis. Findings on 12-lead electrocardiography were compared between 18 patients with FMFamyloidosis and 18 age-And sex-matched control subjects. Repolarization and dispersion parameters were computed with designated computer software, and results of the 5 beats were subsequently averaged. There were no statistically significant differences between the groups as to average corrected QT interval length, average QTd interval, average QT corrected dispersion, or QT dispersion ratio. JT dispersion and JT corrected dispersion were also similar in both groups. In conclusion, patients with FMFamyloidosis seem to have QT and JT dispersion parameters similar to those of healthy subjects. Future research and longer follow-ups should be conducted in order to evaluate the prognostic importance of repolarization dispersion parameters in amyloidosis of FMF.

Original languageEnglish
Pages (from-to)1945-1948
Number of pages4
JournalRheumatology International
Volume32
Issue number7
DOIs
StatePublished - Jul 2012

Keywords

  • Amyloidosis
  • Arrhythmia
  • Cardiovascular disease
  • Familial Mediterranean fever
  • JT dispersion (JTd)
  • QT dispersion (QTd)

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