TY - JOUR
T1 - Pyroptotic death storms and cytopenia
AU - Croker, Ben A.
AU - O'Donnell, Joanne A.
AU - Gerlic, Motti
N1 - Funding Information:
This work was supported by NIH Grant 1R56AI103352-01A1 , a Dora Lush Scholarship to JAO, and additional support from the Victorian State Government Operational Infrastructure Support.
PY - 2014/2
Y1 - 2014/2
N2 - For over two decades, we have embraced the cytokine storm theory to explain sepsis, severe sepsis and septic shock. The failure of numerous large-scale clinical trials, which aimed to treat sepsis by neutralizing inflammatory cytokines and LPS, indicates that alternative pathophysiological mechanisms are likely to account for sepsis and the associated immune suppression in patients with severe infection. Recent insights that extricate pyroptotic death from inflammatory cytokine production in vivo have highlighted a need to investigate the consequences of apoptotic and non-apoptotic death in contributing to cytopenia and immune suppression. In this review, we will focus on the biochemical and cellular mechanisms controlling pyroptosis, a Caspase-1/11 dependent form of cell death during infection.
AB - For over two decades, we have embraced the cytokine storm theory to explain sepsis, severe sepsis and septic shock. The failure of numerous large-scale clinical trials, which aimed to treat sepsis by neutralizing inflammatory cytokines and LPS, indicates that alternative pathophysiological mechanisms are likely to account for sepsis and the associated immune suppression in patients with severe infection. Recent insights that extricate pyroptotic death from inflammatory cytokine production in vivo have highlighted a need to investigate the consequences of apoptotic and non-apoptotic death in contributing to cytopenia and immune suppression. In this review, we will focus on the biochemical and cellular mechanisms controlling pyroptosis, a Caspase-1/11 dependent form of cell death during infection.
UR - http://www.scopus.com/inward/record.url?scp=84890882261&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2013.12.002
DO - 10.1016/j.coi.2013.12.002
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C2 - 24556409
AN - SCOPUS:84890882261
SN - 0952-7915
VL - 26
SP - 128
EP - 137
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -