Pulsed electric fields for cardiac ablation and beyond: A state-of-the-art review

Elad Maor; Alan Sugrue; Chance Witt; Vaibhav R. Vaidya; Christopher V. DeSimone; Samuel J. Asirvatham; Suraj Kapa

doi:10.1016/j.hrthm.2019.01.012

Pulsed electric fields for cardiac ablation and beyond: A state-of-the-art review

Elad Maor, Alan Sugrue, Chance Witt, Vaibhav R. Vaidya, Christopher V. DeSimone, Samuel J. Asirvatham, Suraj Kapa^*

^*Corresponding author for this work

Cardiology

Mayo Clinic Rochester, MN

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Irreversible electroporation (IRE) occurs when a strong, pulsed electric field (PEF) causes permeabilization of the cell membrane, leading to cellular homeostasis disruption and cell death. IRE is a Food and Drug Administration–approved treatment of tumor ablation and has been gaining attention in cardiology as an ablation modality. Applications of PEF in cardiology are vast and include atrial fibrillation, ventricular fibrillation, septal ablation, and targeting vascular structures. PEF has appealing characteristics, including the ability to be tissue specific and its nonthermal nature. This review provides information on the biophysics and mechanisms of IRE, summarizes key studies and applications to date, and provides insight into future applications.

Original language	English
Pages (from-to)	1112-1120
Number of pages	9
Journal	Heart Rhythm
Volume	16
Issue number	7
DOIs	https://doi.org/10.1016/j.hrthm.2019.01.012
State	Published - Jul 2019

Keywords

Ablation
Electroporation
Irreversible electroporation
Pulsed electric fields
Radiofrequency

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.hrthm.2019.01.012

Cite this

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abstract = "Irreversible electroporation (IRE) occurs when a strong, pulsed electric field (PEF) causes permeabilization of the cell membrane, leading to cellular homeostasis disruption and cell death. IRE is a Food and Drug Administration–approved treatment of tumor ablation and has been gaining attention in cardiology as an ablation modality. Applications of PEF in cardiology are vast and include atrial fibrillation, ventricular fibrillation, septal ablation, and targeting vascular structures. PEF has appealing characteristics, including the ability to be tissue specific and its nonthermal nature. This review provides information on the biophysics and mechanisms of IRE, summarizes key studies and applications to date, and provides insight into future applications.",

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AU - Asirvatham, Samuel J.

AU - Kapa, Suraj

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Pulsed electric fields for cardiac ablation and beyond: A state-of-the-art review

Abstract

Keywords

UN SDGs

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