Pulmonary toxicity after radiation and bleomycin: A review

Raphael Catane, James G. Schwade, Andrew T. Turrisi, Bruce L. Webber, Franco M. Muggia

Research output: Contribution to journalArticlepeer-review


The effects of bleomycin (BLM) and radiation on the lung are histologically similar. Animal studies have indicated additive or synergistic effects from these 2 agents. Review of the literature regarding clinical studies using BLM and irradiation indicates that the incidence of pulmonary toxicity increases when bleomycin is administered in conjunction with radiotherapy to the thorax. Of 115 patients treated simultaneously with BLM and radiation to the thorax, 22 (19%) suffered pulmonary toxicity that was fatal in 11 (10%).

Original languageEnglish
Pages (from-to)1513-1518
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number9
StatePublished - Sep 1979
Externally publishedYes


  • Bleomycin
  • Pulmonary toxicity
  • Radiotherapy


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