The effects of bleomycin (BLM) and radiation on the lung are histologically similar. Animal studies have indicated additive or synergistic effects from these 2 agents. Review of the literature regarding clinical studies using BLM and irradiation indicates that the incidence of pulmonary toxicity increases when bleomycin is administered in conjunction with radiotherapy to the thorax. Of 115 patients treated simultaneously with BLM and radiation to the thorax, 22 (19%) suffered pulmonary toxicity that was fatal in 11 (10%).
|Number of pages||6|
|Journal||International Journal of Radiation Oncology Biology Physics|
|State||Published - Sep 1979|
- Pulmonary toxicity