Pulmonary toxicity after radiation and bleomycin: A review

Raphael Catane; James G. Schwade; Andrew T. Turrisi; Bruce L. Webber; Franco M. Muggia

doi:10.1016/0360-3016(79)90761-2

Pulmonary toxicity after radiation and bleomycin: A review

Raphael Catane, James G. Schwade, Andrew T. Turrisi, Bruce L. Webber, Franco M. Muggia

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of bleomycin (BLM) and radiation on the lung are histologically similar. Animal studies have indicated additive or synergistic effects from these 2 agents. Review of the literature regarding clinical studies using BLM and irradiation indicates that the incidence of pulmonary toxicity increases when bleomycin is administered in conjunction with radiotherapy to the thorax. Of 115 patients treated simultaneously with BLM and radiation to the thorax, 22 (19%) suffered pulmonary toxicity that was fatal in 11 (10%).

Original language	English
Pages (from-to)	1513-1518
Number of pages	6
Journal	International Journal of Radiation Oncology Biology Physics
Volume	5
Issue number	9
DOIs	https://doi.org/10.1016/0360-3016(79)90761-2
State	Published - Sep 1979
Externally published	Yes

Keywords

Bleomycin
Pulmonary toxicity
Radiotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0360-3016(79)90761-2

Cite this

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keywords = "Bleomycin, Pulmonary toxicity, Radiotherapy",

author = "Raphael Catane and Schwade, {James G.} and Turrisi, {Andrew T.} and Webber, {Bruce L.} and Muggia, {Franco M.}",

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AU - Webber, Bruce L.

AU - Muggia, Franco M.

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KW - Bleomycin

KW - Pulmonary toxicity

KW - Radiotherapy

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Pulmonary toxicity after radiation and bleomycin: A review

Abstract

Keywords

UN SDGs

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