Pulmonary Manifestations in Familial Mediterranean Fever

Nurit Tweezer-Zaks, Pnina Langevitz, Einat Rabinovich, Avi Livneh

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Although probably existing since ancient times, familial Mediterranean fever (FMF) was not recognized as a unique entity until 1945, when Siegal (1) described 10 cases of ‘‘benign paroxysmal peritonitis.’’ Since then, this condition has been given a variety of names (e.g., hereditary recurrent polyserositis, periodic disease, Armenian disease), emphasizing its genetic and episodic nature and the geographic distribution. FMF is characterized by recurrent episodes of fever and serositis, involving primarily the peritoneum (affecting 95% of patients), the pleura (40% of patients) and the synovial membrane of the joints (75% of patients). Typical febrile episodes of skin rash (erysipelas-like erythema), pericarditis, scrotal pain, and myalgia occurless frequently. The poorly understood leg pain, together with the rare manifestation of protracted febrile myalgia, the uncommon development of chronic arthritis and the nephropathic AA amyloidosis complete the clinical spectrum (2).

Original languageEnglish
Title of host publicationTropical Lung Disease, Second Edition
Subtitle of host publicationVolume 211
PublisherCRC Press
Number of pages10
ISBN (Electronic)9780849362439
ISBN (Print)0824726871, 9780824726874
StatePublished - 1 Jan 2005


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