Pulmonary hypertension in infants with congenital heart defects: Are leukotrienes involved?

A. Serraf; J. P. Gascard; J. Bruniaux; C. Labat; C. Planche; C. Brink

doi:10.1080/09629359791451

Pulmonary hypertension in infants with congenital heart defects: Are leukotrienes involved?

A. Serraf, J. P. Gascard, J. Bruniaux, C. Labat, C. Planche, C. Brink^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The circulating levels of leukotriene E₄ in infants with congenital heart defects, increased pulmonary blood flow and pulmonary arterial hypertension, were determined and compared with infants with decreased pulmonary blood flow (Tetralogy of Fallot). There was no correlation (r = 0.38) between the pulmonary arterial pressure (56 ± 4 mmHg) and the leukotriene E₄ levels (1.37 ± 0.67 ng/ml blood) measured in peripheral blood samples from the hypertensive group prior to surgery. There was considerable variation in the detectable leukotriene E₄ levels in blood samples from different patients. The levels detected in the blood samples between the two groups of patients was similar. These data suggest that neither the surgical repair during cardiopulmonary bypass nor the pulmonary hypertension appeared to modify the leukotriene E₄ blood levels in the small number of patients studied.

Original language	English
Pages (from-to)	323-326
Number of pages	4
Journal	Mediators of Inflammation
Volume	6
Issue number	5-6
DOIs	https://doi.org/10.1080/09629359791451
State	Published - 1997
Externally published	Yes

Keywords

Cardiovascular surgery
Congenital heart defects
Extracorporeal circulation
Leukotrienes
Pulmonary hypertension

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10.1080/09629359791451

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title = "Pulmonary hypertension in infants with congenital heart defects: Are leukotrienes involved?",

abstract = "The circulating levels of leukotriene E4 in infants with congenital heart defects, increased pulmonary blood flow and pulmonary arterial hypertension, were determined and compared with infants with decreased pulmonary blood flow (Tetralogy of Fallot). There was no correlation (r = 0.38) between the pulmonary arterial pressure (56 ± 4 mmHg) and the leukotriene E4 levels (1.37 ± 0.67 ng/ml blood) measured in peripheral blood samples from the hypertensive group prior to surgery. There was considerable variation in the detectable leukotriene E4 levels in blood samples from different patients. The levels detected in the blood samples between the two groups of patients was similar. These data suggest that neither the surgical repair during cardiopulmonary bypass nor the pulmonary hypertension appeared to modify the leukotriene E4 blood levels in the small number of patients studied.",

keywords = "Cardiovascular surgery, Congenital heart defects, Extracorporeal circulation, Leukotrienes, Pulmonary hypertension",

author = "A. Serraf and Gascard, {J. P.} and J. Bruniaux and C. Labat and C. Planche and C. Brink",

year = "1997",

doi = "10.1080/09629359791451",

language = "אנגלית",

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T1 - Pulmonary hypertension in infants with congenital heart defects

T2 - Are leukotrienes involved?

AU - Serraf, A.

AU - Gascard, J. P.

AU - Bruniaux, J.

AU - Labat, C.

AU - Planche, C.

AU - Brink, C.

PY - 1997

Y1 - 1997

N2 - The circulating levels of leukotriene E4 in infants with congenital heart defects, increased pulmonary blood flow and pulmonary arterial hypertension, were determined and compared with infants with decreased pulmonary blood flow (Tetralogy of Fallot). There was no correlation (r = 0.38) between the pulmonary arterial pressure (56 ± 4 mmHg) and the leukotriene E4 levels (1.37 ± 0.67 ng/ml blood) measured in peripheral blood samples from the hypertensive group prior to surgery. There was considerable variation in the detectable leukotriene E4 levels in blood samples from different patients. The levels detected in the blood samples between the two groups of patients was similar. These data suggest that neither the surgical repair during cardiopulmonary bypass nor the pulmonary hypertension appeared to modify the leukotriene E4 blood levels in the small number of patients studied.

AB - The circulating levels of leukotriene E4 in infants with congenital heart defects, increased pulmonary blood flow and pulmonary arterial hypertension, were determined and compared with infants with decreased pulmonary blood flow (Tetralogy of Fallot). There was no correlation (r = 0.38) between the pulmonary arterial pressure (56 ± 4 mmHg) and the leukotriene E4 levels (1.37 ± 0.67 ng/ml blood) measured in peripheral blood samples from the hypertensive group prior to surgery. There was considerable variation in the detectable leukotriene E4 levels in blood samples from different patients. The levels detected in the blood samples between the two groups of patients was similar. These data suggest that neither the surgical repair during cardiopulmonary bypass nor the pulmonary hypertension appeared to modify the leukotriene E4 blood levels in the small number of patients studied.

KW - Cardiovascular surgery

KW - Congenital heart defects

KW - Extracorporeal circulation

KW - Leukotrienes

KW - Pulmonary hypertension

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Pulmonary hypertension in infants with congenital heart defects: Are leukotrienes involved?

Abstract

Keywords

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