A 2 yr old boy presented with nephrotic syndrome and was treated with steroids and diuretics. A partial remission followed during which he underwent a severe attack of chickenpox treated with chickenpox convalescent plasma and lymphocytes, and with arabinoside. Following improvement he returned home for 1 mth. The child was readmitted when his condition suddenly deteriorated and he was treated with steroids and diuretics. On the 21st day breathlessness, cyanosis, hepatomegaly and tachycardia developed and he died shortly after. At postmortem, thrombosis of the main pulmonary artery and its branches was found. The right kidney contained a small infarct. Microscopically, the kidneys showed minimal changes and mild nephrocalcinosis. The increased tendency to thrombosis is stressed in nephrotic children with hypovolemia who receive steroids and diuretic drugs.
|State||Published - 1974|