Psychophysiological whole-brain network clustering based on connectivity dynamics analysis in naturalistic conditions

Gal Raz*, Lavi Shpigelman, Yael Jacob, Tal Gonen, Yoav Benjamini, Talma Hendler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We introduce a novel method for delineating context-dependent functional brain networks whose connectivity dynamics are synchronized with the occurrence of a specific psychophysiological process of interest. In this method of context-related network dynamics analysis (CRNDA), a continuous psychophysiological index serves as a reference for clustering the whole-brain into functional networks. We applied CRNDA to fMRI data recorded during the viewing of a sadness-inducing film clip. The method reliably demarcated networks in which temporal patterns of connectivity related to the time series of reported emotional intensity. Our work successfully replicated the link between network connectivity and emotion rating in an independent sample group for seven of the networks. The demarcated networks have clear common functional denominators. Three of these networks overlap with distinct empathy-related networks, previously identified in distinct sets of studies. The other networks are related to sensorimotor processing, language, attention, and working memory. The results indicate that CRNDA, a data-driven method for network clustering that is sensitive to transient connectivity patterns, can productively and reliably demarcate networks that follow psychologically meaningful processes. Hum Brain Mapp 37:4654–4672, 2016.

Original languageEnglish
Pages (from-to)4654-4672
Number of pages19
JournalHuman Brain Mapping
Issue number12
StatePublished - 1 Dec 2016


  • emotion
  • fMRI
  • functional connectivity
  • network dynamics


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