Psoriasis comorbidity affects multiple sclerosis neurological progression: a retrospective case – control analysis

G. Miron*, M. Gurevich, S. Baum, A. Achiron, A. Barzilai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Multiple sclerosis (MS) and psoriasis are inflammatory disorders, with epidemiological and biological associations. The impact of one disease on the course of the other has not been studied. Objective: To characterize patients with psoriasis and MS, and to assess whether psoriasis comorbidity affected the progression of MS. Methods: A retrospective case–control study. Patients with psoriasis comorbidity were identified from 3456 patients included in the Sheba Hospital Multiple Sclerosis Center database. Clinical and demographical characteristics and MS progression-related outcomes in patients whose follow-up exceeded 5 years were analysed and compared to those of a matched control cohort of MS-only (MSO) patients. Results: Forty-five (1.3%) MS patients had psoriasis comorbidity. Psoriasis preceded MS in 35 (78%) cases. The psoriasis was defined as mild, moderate and severe in 24 (53%), twelve (27%) and nine (20%) cases respectively. MS progression-related outcomes were evaluated in 35 patients that had follow-up over 5 years. Patients with psoriasis onset preceding relapsing-remitting MS (RRMS) had slower progression of disease compared to MSO patients, as manifested by a longer time to second relapse (P < 0.01) and a longer time to significant neurological disability scores (P < 0.03). Conclusion: Psoriasis comorbidity preceding the onset of MS is associated with slower progression of disability.

Original languageEnglish
Pages (from-to)2055-2061
Number of pages7
JournalJournal of the European Academy of Dermatology and Venereology
Issue number12
StatePublished - Dec 2017


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