TY - JOUR
T1 - Pseudotumor cerebri in systemic lupus erythematosus
AU - Green, Leslie
AU - Vinker, Shlomo
AU - Amital, Howard
AU - Amir, Tanay
AU - Bar-Dayan, Yaron
AU - Levi, Yair
AU - Schoenfeld, Yehuda
PY - 1995/10
Y1 - 1995/10
N2 - Objective: To assess the association between pseudotumor cerebri (PC) andsystemic lupus erythematosus (SLE), and to seek a pathogenic mechanism that may elucidate the appearance of PC in patients with SLE. Data Source: Original English articles having the terms SLE, PC, or benign intracranial hypertension in their titles were identified by Medline search. In addition we report three new patients with this association. Study Synthesis: Thirteen articles were found and 21 patients were analyzed. Data Extraction: Of the reported 21 patients, 18 were previously reported and 3new patients with coexisting PC and SLE are described. The clinical characteristics of the patients is presented. Patients with PC and SLE generally had a more severe course of SLE; renal involvement occurred in 79%, massive proteinuria in 47%, and hematologic abnormalities were detected in a third. A hypercoagulable state manifest by either recurrent thromboembolic events or a high anti-cardiolipin antibody titer was detected in 58% of the patients described. Conclusions: The association of PC and SLE is probably not coincidental. The high prevalence of serologic or clinical evidence of a hypercoagulable state suggests that microscopical thromboembolic events play a role in the genesis of PC.
AB - Objective: To assess the association between pseudotumor cerebri (PC) andsystemic lupus erythematosus (SLE), and to seek a pathogenic mechanism that may elucidate the appearance of PC in patients with SLE. Data Source: Original English articles having the terms SLE, PC, or benign intracranial hypertension in their titles were identified by Medline search. In addition we report three new patients with this association. Study Synthesis: Thirteen articles were found and 21 patients were analyzed. Data Extraction: Of the reported 21 patients, 18 were previously reported and 3new patients with coexisting PC and SLE are described. The clinical characteristics of the patients is presented. Patients with PC and SLE generally had a more severe course of SLE; renal involvement occurred in 79%, massive proteinuria in 47%, and hematologic abnormalities were detected in a third. A hypercoagulable state manifest by either recurrent thromboembolic events or a high anti-cardiolipin antibody titer was detected in 58% of the patients described. Conclusions: The association of PC and SLE is probably not coincidental. The high prevalence of serologic or clinical evidence of a hypercoagulable state suggests that microscopical thromboembolic events play a role in the genesis of PC.
KW - SLE
KW - neuropsychiatric symptoms
KW - pseudotumor cerebri
UR - http://www.scopus.com/inward/record.url?scp=0028800989&partnerID=8YFLogxK
U2 - 10.1016/S0049-0172(95)80023-9
DO - 10.1016/S0049-0172(95)80023-9
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AN - SCOPUS:0028800989
SN - 0049-0172
VL - 25
SP - 103
EP - 108
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
IS - 2
ER -