Pseudoexfoliation: An ocular finding with possible systemic implications

Uri Aviv, Daniel Ben Ner, Nardine Sharif, Zvi Gur, Asaf Achiron

Research output: Contribution to journalArticlepeer-review


Pseudoexfoliation syndrome (PES) is a common age-related disorder affecting 60–70 million people worldwide. Patients with PES have abnormal production and deposition of fibrillar material in the anterior chamber of the eye. These exfoliated fibrils, easily detected by ocular slit-lamp examination, have also been found to exist systematically in the skin, heart, lungs, liver and kidneys. Recently, a myriad of studies have associated PES with systemic conditions such as increased vascular risk, risk of dementia and inflammatory state. We review here the most current literature on the systemic implications of PES. Our aim is to encourage further studies on this important clinical entity.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalIsrael Medical Association Journal
Issue number1
StatePublished - Jan 2017


  • Microfibrils
  • Pseudoexfoliation syndrome (PES)
  • Slit-lamp examination


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