A strong linkage, supported by data from animal models and human patients, exists between aberrant overexpression of protooncogenes and autoimmune states. However, overexpression is not always the rule. Some protooncogenes are underexpressed or demonstrate lower activity, e.g. p21ras in insulin-dependent diabetes mellitus, and in the same disease, different protooncogenes may be up- and down-regulated simultaneously. This indicates that the expression and function of different protooncogenes may differ among autoimmune diseases. It also indicates that the role of each protooncogene in the pathogenesis of a particular autoimmune disease should be determined separately.
|Number of pages||5|
|Journal||Israel Journal of Medical Sciences|
|State||Published - Apr 1997|