Proton double-quantum filtered MRI - A new method for imaging ordered tissues

Liat Tsoref, Hadassah Shinar, Yoshiteru Seo, Uzi Eliav, Gil Navon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The imaging of connective tissues such as cartilage and tendons using standard MRI techniques is hampered by their low signal relative to the surrounding tissues. 1H double-quantum filtered (DQF) MRI is an imaging method that detects molecules associated with ordered structures, while the signal from isotropic fluids is filtered out, thus creating a new type of contrast. The technique is demonstrated on an intact rat tail, where the image of the tendons is highlighted. Although the signal-to-noise ratio is inferior to that in gradient-echo MRI, the contrast between the tendons and the surrounding tissues is significantly better in the DQF MRI. It is demonstrated how, by adjusting the parameters of the DQF imaging pulse sequence, one can modify the contrast and enhance the images of specific compartments within an organ. A comparison with 2H DQF imaging of the same tissue is also given.

Original languageEnglish
Pages (from-to)720-726
Number of pages7
JournalMagnetic Resonance in Medicine
Issue number5
StatePublished - Nov 1998


  • Connective tissues
  • Tendon


Dive into the research topics of 'Proton double-quantum filtered MRI - A new method for imaging ordered tissues'. Together they form a unique fingerprint.

Cite this