Prothrombin Complex Concentrate before Urgent Surgery in Patients Treated with Rivaroxaban and Apixaban

Merav Barzilai, Ilya Kirgner, Arza Steimatzky, Dalit Salzer Gotler, Yulia Belnick, Adi Shacham-Abulafia, Irit Avivi, Pia Raanani, Vered Yahalom, Sigal Nakav, David Varon, Ethan Yussim, Gil N. Bachar, Galia Spectre*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduction: Patients treated with direct Xa inhibitors may require urgent surgery. Administration of prothrombin complex concentrate (PCC) in this setting is common; however, it is based on limited experience in healthy volunteers. Objective: To characterize the population receiving PCC for apixaban/rivaroxaban reversal prior to an urgent surgery and evaluate its efficacy and safety. Methods: This was a retrospective study in 2 tertiary hospitals. Bleeding was evaluated based on surgical reports, hemoglobin drop, and the use of blood products or additional PCC during 48 h. Safety measures were thrombotic complications and 30-day mortality. Results: Sixty-two patients aged 80.7 ± 9 years, treated with apixaban (39.63%) or rivaroxaban (23.37%), received PCC before an urgent surgery/procedure. Most underwent abdominal operation (61%), orthopedic surgery (13%), or transhepatic cholecystostomy insertion (10%). Bleeding during surgery was reported in 3 patients (5%), no patient required additional PCC, and 16 patients (26%) received packed cells (median: 1 unit, range: 1-5). The 30-day mortality and thrombosis rates were 21% (n = 13) and 3% (n = 2), respectively. The cause of death was related to the primary disease, most commonly sepsis. No patient died due to bleeding/thrombosis. Conclusions: Our results support the use of PCC to achieve hemostasis in patients treated with Xa inhibitors prior to an urgent surgery.

Original languageEnglish
Pages (from-to)266-271
Number of pages6
JournalActa Haematologica
Issue number3
StatePublished - 1 Jun 2020


  • Apixaban
  • Prothrombin complex concentrate
  • Rivaroxaban
  • Urgent surgery
  • Xa inhibitors


Dive into the research topics of 'Prothrombin Complex Concentrate before Urgent Surgery in Patients Treated with Rivaroxaban and Apixaban'. Together they form a unique fingerprint.

Cite this