Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

Michal Harel, Rona Ortenberg, Siva Karthik Varanasi, Kailash Chandra Mangalhara, Mariya Mardamshina, Ettai Markovits, Erez N. Baruch, Victoria Tripple, May Arama-Chayoth, Eyal Greenberg, Anjana Shenoy, Ruveyda Ayasun, Naama Knafo, Shihao Xu, Liat Anafi, Gali Yanovich-Arad, Georgina D. Barnabas, Shira Ashkenazi, Michal J. Besser, Jacob SchachterMarcus Bosenberg, Gerald S. Shadel, Iris Barshack, Susan M. Kaech, Gal Markel*, Tamar Geiger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Proteomic profiling of melanomas from patients undergoing immunotherapy reveals key mediators of tumor immunogenicity.

Original languageEnglish
Pages (from-to)236-250.e18
JournalCell
Volume179
Issue number1
DOIs
StatePublished - 19 Sep 2019

Keywords

  • anti-PD-1
  • cancer metabolism
  • immune checkpoint inhibitors
  • immunotherapy
  • lipid metabolism
  • mass spectrometry
  • melanoma
  • mitochondrial metabolism
  • proteomics
  • tumor-infiltrating lymphocytes

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