Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

Michal Harel; Rona Ortenberg; Siva Karthik Varanasi; Kailash Chandra Mangalhara; Mariya Mardamshina; Ettai Markovits; Erez N. Baruch; Victoria Tripple; May Arama-Chayoth; Eyal Greenberg; Anjana Shenoy; Ruveyda Ayasun; Naama Knafo; Shihao Xu; Liat Anafi; Gali Yanovich-Arad; Georgina D. Barnabas; Shira Ashkenazi; Michal J. Besser; Jacob Schachter; Marcus Bosenberg; Gerald S. Shadel; Iris Barshack; Susan M. Kaech; Gal Markel; Tamar Geiger

doi:10.1016/j.cell.2019.08.012

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

Michal Harel, Rona Ortenberg, Siva Karthik Varanasi, Kailash Chandra Mangalhara, Mariya Mardamshina, Ettai Markovits, Erez N. Baruch, Victoria Tripple, May Arama-Chayoth, Eyal Greenberg, Anjana Shenoy, Ruveyda Ayasun, Naama Knafo, Shihao Xu, Liat Anafi, Gali Yanovich-Arad, Georgina D. Barnabas, Shira Ashkenazi, Michal J. Besser, Jacob SchachterMarcus Bosenberg, Gerald S. Shadel, Iris Barshack, Susan M. Kaech, Gal Markel^*, Tamar Geiger

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

239 Scopus citations

Abstract

Proteomic profiling of melanomas from patients undergoing immunotherapy reveals key mediators of tumor immunogenicity.

Original language	English
Pages (from-to)	236-250.e18
Journal	Cell
Volume	179
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2019.08.012
State	Published - 19 Sep 2019

Funding

Funders	Funder number
Israel Innovation Authority
Lemelbaum family
NOMIS Center Postdoctoral Foundation
Samueli Foundation
National Institutes of Health	R01 CA216102
National Cancer Institute	P01CA128814
Melanoma Research Alliance
National Cancer Center

Keywords

anti-PD-1
cancer metabolism
immune checkpoint inhibitors
immunotherapy
lipid metabolism
mass spectrometry
melanoma
mitochondrial metabolism
proteomics
tumor-infiltrating lymphocytes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cell.2019.08.012

Cite this

Harel, M., Ortenberg, R., Varanasi, S. K., Mangalhara, K. C., Mardamshina, M., Markovits, E., Baruch, E. N., Tripple, V., Arama-Chayoth, M., Greenberg, E., Shenoy, A., Ayasun, R., Knafo, N., Xu, S., Anafi, L., Yanovich-Arad, G., Barnabas, G. D., Ashkenazi, S., Besser, M. J., ... Geiger, T. (2019). Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. Cell, 179(1), 236-250.e18. https://doi.org/10.1016/j.cell.2019.08.012

@article{2775e80a970f47499cb81a5ee6a2a174,

title = "Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence",

abstract = "Proteomic profiling of melanomas from patients undergoing immunotherapy reveals key mediators of tumor immunogenicity.",

keywords = "anti-PD-1, cancer metabolism, immune checkpoint inhibitors, immunotherapy, lipid metabolism, mass spectrometry, melanoma, mitochondrial metabolism, proteomics, tumor-infiltrating lymphocytes",

author = "Michal Harel and Rona Ortenberg and Varanasi, {Siva Karthik} and Mangalhara, {Kailash Chandra} and Mariya Mardamshina and Ettai Markovits and Baruch, {Erez N.} and Victoria Tripple and May Arama-Chayoth and Eyal Greenberg and Anjana Shenoy and Ruveyda Ayasun and Naama Knafo and Shihao Xu and Liat Anafi and Gali Yanovich-Arad and Barnabas, {Georgina D.} and Shira Ashkenazi and Besser, {Michal J.} and Jacob Schachter and Marcus Bosenberg and Shadel, {Gerald S.} and Iris Barshack and Kaech, {Susan M.} and Gal Markel and Tamar Geiger",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

day = "19",

doi = "10.1016/j.cell.2019.08.012",

language = "אנגלית",

volume = "179",

pages = "236--250.e18",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

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Harel, M, Ortenberg, R, Varanasi, SK, Mangalhara, KC, Mardamshina, M, Markovits, E, Baruch, EN, Tripple, V, Arama-Chayoth, M, Greenberg, E, Shenoy, A, Ayasun, R, Knafo, N, Xu, S, Anafi, L, Yanovich-Arad, G, Barnabas, GD, Ashkenazi, S, Besser, MJ , Schachter, J, Bosenberg, M, Shadel, GS, Barshack, I, Kaech, SM, Markel, G & Geiger, T 2019, 'Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence', Cell, vol. 179, no. 1, pp. 236-250.e18. https://doi.org/10.1016/j.cell.2019.08.012

TY - JOUR

T1 - Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

AU - Harel, Michal

AU - Ortenberg, Rona

AU - Varanasi, Siva Karthik

AU - Mangalhara, Kailash Chandra

AU - Mardamshina, Mariya

AU - Markovits, Ettai

AU - Baruch, Erez N.

AU - Tripple, Victoria

AU - Arama-Chayoth, May

AU - Greenberg, Eyal

AU - Shenoy, Anjana

AU - Ayasun, Ruveyda

AU - Knafo, Naama

AU - Xu, Shihao

AU - Anafi, Liat

AU - Yanovich-Arad, Gali

AU - Barnabas, Georgina D.

AU - Ashkenazi, Shira

AU - Besser, Michal J.

AU - Schachter, Jacob

AU - Bosenberg, Marcus

AU - Shadel, Gerald S.

AU - Barshack, Iris

AU - Kaech, Susan M.

AU - Markel, Gal

AU - Geiger, Tamar

PY - 2019/9/19

Y1 - 2019/9/19

N2 - Proteomic profiling of melanomas from patients undergoing immunotherapy reveals key mediators of tumor immunogenicity.

AB - Proteomic profiling of melanomas from patients undergoing immunotherapy reveals key mediators of tumor immunogenicity.

KW - anti-PD-1

KW - cancer metabolism

KW - immune checkpoint inhibitors

KW - immunotherapy

KW - lipid metabolism

KW - mass spectrometry

KW - melanoma

KW - mitochondrial metabolism

KW - proteomics

KW - tumor-infiltrating lymphocytes

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U2 - 10.1016/j.cell.2019.08.012

DO - 10.1016/j.cell.2019.08.012

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AN - SCOPUS:85072162948

SN - 0092-8674

VL - 179

SP - 236-250.e18

JO - Cell

JF - Cell

IS - 1

ER -

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

Abstract

Funding

Keywords

UN SDGs

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