Proteomic analysis of SETD6 interacting proteins

Ofir Cohn, Ayelet Chen, Michal Feldman, Dan Levy

Research output: Contribution to journalArticlepeer-review


SETD6 (SET-domain-containing protein 6) is a mono-methyltransferase that has been shown to methylate RelA and H2AZ. Using a proteomic approach we recently identified several new SETD6 substrates. To identify novel SETD6 interacting proteins, SETD6 was immunoprecipitated (IP) from Human erythromyeloblastoid leukemia K562 cells. SETD6 binding proteins were subjected to mass-spectrometry analysis resulting in 115 new SETD6 binding candidates. STRING database was used to map the SETD6 interactome network. Network enrichment analysis of biological processes with Gene Ontology (GO) database, identified three major groups; metabolic processes, muscle contraction and protein folding.

Original languageEnglish
Pages (from-to)799-802
Number of pages4
JournalData in Brief
StatePublished - 1 Mar 2016
Externally publishedYes


  • Interactome
  • Mass spectrometry
  • SETD6


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