Proteins of human follicular fluid: the blood follicle barrier

R. Shalgi, P. Kraicer, A. Rimon, M. Pinto, N. Soferman

Research output: Contribution to journalArticlepeer-review


The composition of the proteins of human follicular fluid and blood plasma was compared. The protein concentration of both was the same. No follicle specific proteins were detected. However, the relative proportions of the proteins were different. Concentrations of albumin, transferrin, IgG, fibrinogen, α2 macroglobulin, IgM, and β1 lipoprotein were studied. Low molecular weight proteins like albumin accumulate in the follicle whereas high molecular weight protein like β1 lipoprotein and IgM are excluded. The blood follicle barrier behaves like a molecular sieve, which allows passage of protein in inverse proportion to molecular weight but, paradoxically, not in inverse proportion to molecular size.

Original languageEnglish
Pages (from-to)429-434
Number of pages6
JournalUnknown Journal
Issue number6
StatePublished - 1973


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