Proteins: Coexistence of stability and flexibility

Shlomi Reuveni; Rony Granek; Joseph Klafter

doi:10.4108/ICST.VALUETOOLS2008.4241

Proteins: Coexistence of stability and flexibility

Shlomi Reuveni, Rony Granek, Joseph Klafter

Ben-Gurion University of the Negev

Research output: Contribution to conference › Paper › peer-review

1 Scopus citations

Abstract

We introduce an equation for protein native topology based on recent analysis of data from the Protein Data Bank and on a generalization of the Landau-Peierls instability criterion for fractals. The equation relates the protein fractal dimension d_f, the spectral dimension d_s, and the number of amino acids N. Deviations from the equation may render a protein unfolded. The fractal nature of proteins is shown to bridge their seemingly conflicting properties of stability and flexibility. Over 500 proteins have been analyzed (d_f, d_s, and N) and found to obey this equation of state.

Original language	English
DOIs	https://doi.org/10.4108/ICST.VALUETOOLS2008.4241
State	Published - 2008
Event	3rd International Conference on Performance Evaluation Methodologies and Tools, VALUETOOLS 2008 - Athens, Greece Duration: 20 Oct 2008 → 24 Oct 2008

Conference

Conference	3rd International Conference on Performance Evaluation Methodologies and Tools, VALUETOOLS 2008
Country/Territory	Greece
City	Athens
Period	20/10/08 → 24/10/08

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10.4108/ICST.VALUETOOLS2008.4241

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Proteins: Coexistence of stability and flexibility

Abstract

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