Protein phosphatase 2Cα expression in normal human tissues: An immunohistochemical study

Beatriz Lifschitz-Mercer; Yuri Sheinin; Daniella Ben-Meir; Letizia Bramante-Schreiber; Leonor Leider-Trejo; Shulamit Karby; Nechama I. Smorodinsky; Sara Lavi

doi:10.1007/s004180100291

Protein phosphatase 2Cα expression in normal human tissues: An immunohistochemical study

Beatriz Lifschitz-Mercer, Yuri Sheinin, Daniella Ben-Meir, Letizia Bramante-Schreiber, Leonor Leider-Trejo, Shulamit Karby, Nechama I. Smorodinsky, Sara Lavi^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Protein phosphatase (PP2Cα) is a member of the mammalian serine threonine-specific protein phosphatases family. We produced monoclonal antibodies against the recombinant PP2Cα and evaluated the immunoreactivity of normal human tissues. The reactivity was strong in normal skin, the digestive tract, lung, kidney, breast, prostate, endocrine glands, and brain, while it was moderate in the ovary, testis, and liver. Epithelial cells revealed high levels of PP2Cα expression, but stromal cells, including fibroblasts and endothelial cells, showed no or little PP2Cα expression. Given the broad reactivity in endocrine and secreting epithelial cells, we propose that PP2Cα expression might contribute to secretory cell function.

Original language	English
Pages (from-to)	31-39
Number of pages	9
Journal	Histochemistry and Cell Biology
Volume	116
Issue number	1
DOIs	https://doi.org/10.1007/s004180100291
State	Published - 2001

Keywords

Histology
Human
Immunohistochemistry
Protein phosphatase 2Cα
Tissue distribution

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abstract = "Protein phosphatase (PP2Cα) is a member of the mammalian serine threonine-specific protein phosphatases family. We produced monoclonal antibodies against the recombinant PP2Cα and evaluated the immunoreactivity of normal human tissues. The reactivity was strong in normal skin, the digestive tract, lung, kidney, breast, prostate, endocrine glands, and brain, while it was moderate in the ovary, testis, and liver. Epithelial cells revealed high levels of PP2Cα expression, but stromal cells, including fibroblasts and endothelial cells, showed no or little PP2Cα expression. Given the broad reactivity in endocrine and secreting epithelial cells, we propose that PP2Cα expression might contribute to secretory cell function.",

keywords = "Histology, Human, Immunohistochemistry, Protein phosphatase 2Cα, Tissue distribution",

author = "Beatriz Lifschitz-Mercer and Yuri Sheinin and Daniella Ben-Meir and Letizia Bramante-Schreiber and Leonor Leider-Trejo and Shulamit Karby and Smorodinsky, {Nechama I.} and Sara Lavi",

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T1 - Protein phosphatase 2Cα expression in normal human tissues

T2 - An immunohistochemical study

AU - Lifschitz-Mercer, Beatriz

AU - Sheinin, Yuri

AU - Ben-Meir, Daniella

AU - Bramante-Schreiber, Letizia

AU - Leider-Trejo, Leonor

AU - Karby, Shulamit

AU - Smorodinsky, Nechama I.

AU - Lavi, Sara

PY - 2001

Y1 - 2001

N2 - Protein phosphatase (PP2Cα) is a member of the mammalian serine threonine-specific protein phosphatases family. We produced monoclonal antibodies against the recombinant PP2Cα and evaluated the immunoreactivity of normal human tissues. The reactivity was strong in normal skin, the digestive tract, lung, kidney, breast, prostate, endocrine glands, and brain, while it was moderate in the ovary, testis, and liver. Epithelial cells revealed high levels of PP2Cα expression, but stromal cells, including fibroblasts and endothelial cells, showed no or little PP2Cα expression. Given the broad reactivity in endocrine and secreting epithelial cells, we propose that PP2Cα expression might contribute to secretory cell function.

AB - Protein phosphatase (PP2Cα) is a member of the mammalian serine threonine-specific protein phosphatases family. We produced monoclonal antibodies against the recombinant PP2Cα and evaluated the immunoreactivity of normal human tissues. The reactivity was strong in normal skin, the digestive tract, lung, kidney, breast, prostate, endocrine glands, and brain, while it was moderate in the ovary, testis, and liver. Epithelial cells revealed high levels of PP2Cα expression, but stromal cells, including fibroblasts and endothelial cells, showed no or little PP2Cα expression. Given the broad reactivity in endocrine and secreting epithelial cells, we propose that PP2Cα expression might contribute to secretory cell function.

KW - Histology

KW - Human

KW - Immunohistochemistry

KW - Protein phosphatase 2Cα

KW - Tissue distribution

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Protein phosphatase 2Cα expression in normal human tissues: An immunohistochemical study

Abstract

Keywords

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