Protein networks in disease

Trey Ideker, Roded Sharan

Research output: Contribution to journalReview articlepeer-review

Abstract

During a decade of proof-of-principle analysis in model organisms, protein networks have been used to further the study of molecular evolution, to gain insight into the robustness of cells to perturbation, and for assignment of new protein functions. Following these analyses, and with the recent rise of protein interaction measurements in mammals, protein networks are increasingly serving as tools to unravel the molecular basis of disease. We review promising applications of protein networks to disease in four major areas: identifying new disease genes; the study of their network properties; identifying disease-related subnetworks; and network-based disease classification. Applications in infectious disease, personalized medicine, and pharmacology are also forthcoming as the available protein network information improves in quality and coverage.

Original languageEnglish
Pages (from-to)644-652
Number of pages9
JournalGenome Research
Volume18
Issue number4
DOIs
StatePublished - Apr 2008

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