TY - JOUR
T1 - Protein-driven membrane stresses in fusion and fission
AU - Kozlov, Michael M.
AU - McMahon, Harvey T.
AU - Chernomordik, Leonid V.
N1 - Funding Information:
Financial support for MMK from the Israel Science Foundation (ISF) and Marie Curie Network “Virus Entry”, for HMM from the Medical Research Council, UK, and for LVC from the Intramural Research Program of the National Institute of Child Health and Human Development, National Institutes of Health and NIAID, and a National Institutes of Health Intramural Biodefense Research grant is gratefully acknowledged.
PY - 2010/12
Y1 - 2010/12
N2 - Cellular membranes undergo continuous remodeling. Exocytosis and endocytosis, mitochondrial fusion and fission, entry of enveloped viruses into host cells and release of the newly assembled virions, cell-to-cell fusion and cell division, and budding and fusion of transport carriers all proceed via topologically similar, but oppositely ordered, membrane rearrangements. The biophysical similarities and differences between membrane fusion and fission become more evident if we disregard the accompanying biological processes and consider only remodeling of the lipid bilayer. The forces that determine the bilayer propensity to undergo fusion or fission come from proteins and in most cases from membrane-bound proteins. In this review, we consider the mechanistic principles underlying the fusion and fission reactions and discuss the current hypotheses on how specific proteins act in the two types of membrane remodeling.
AB - Cellular membranes undergo continuous remodeling. Exocytosis and endocytosis, mitochondrial fusion and fission, entry of enveloped viruses into host cells and release of the newly assembled virions, cell-to-cell fusion and cell division, and budding and fusion of transport carriers all proceed via topologically similar, but oppositely ordered, membrane rearrangements. The biophysical similarities and differences between membrane fusion and fission become more evident if we disregard the accompanying biological processes and consider only remodeling of the lipid bilayer. The forces that determine the bilayer propensity to undergo fusion or fission come from proteins and in most cases from membrane-bound proteins. In this review, we consider the mechanistic principles underlying the fusion and fission reactions and discuss the current hypotheses on how specific proteins act in the two types of membrane remodeling.
UR - http://www.scopus.com/inward/record.url?scp=78649322086&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2010.06.003
DO - 10.1016/j.tibs.2010.06.003
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
AN - SCOPUS:78649322086
SN - 0968-0004
VL - 35
SP - 699
EP - 706
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 12
ER -