TY - JOUR
T1 - Protective effect of different ophthalmic viscosurgical devices on corneal endothelial cells during phacoemulsification
T2 - Rabbit model
AU - Ben-Eliahu, Shmuel
AU - Tal, Kfir
AU - Milstein, Asher
AU - Levin-Harrus, Tal
AU - Ezov, Nati
AU - Kleinmann, Guy
PY - 2010/11
Y1 - 2010/11
N2 - Purpose: To evaluate the protective effect of different ophthalmic viscosurgical devices on corneal endothelial cells during phacoemulsification in a rabbit model. Setting: Harlan Biotech Israel and Ophthalmology Department, Kaplan Medical Center, Rehovot, Israel. Design: Experimental study. Methods: Rabbit eyes were randomly assigned to 3 equally sized groups. Endothelial cell counts were performed in all eyes before initiation of the study. The aqueous humor was completely replaced by Biolon (sodium hyaluronate 1.0%) in Group A, by a combination of Viscoat (sodium chondroitin sulfate 4.0%-sodium hyaluronate 3.0%) and Provisc (sodium chondroitin sulfate 1.0%) using the soft-shell technique in Group B, and by a combination of Visiol (sodium hyaluronate 2.0%-mannitol 0.5%) and Biolon using the soft-shell technique in Group C. The eyes were exposed to alternating 10 seconds of phacoemulsification and a 10-second pause until a total exposure time of 2.5 minutes elapsed. Endothelial cell counts were repeated 3 days after surgery. Results: The study used 18 rabbit eyes, 6 in each group. Group A had the highest endothelial cell loss (13%) followed by Group B (7%), and Group C (4%). The difference in cell loss between Group C and Group A was statistically significant (P = .037). Conclusion: The study showed the efficiency and advantages of the soft-shell technique using the combination of Visiol and Biolon over Biolon alone. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.
AB - Purpose: To evaluate the protective effect of different ophthalmic viscosurgical devices on corneal endothelial cells during phacoemulsification in a rabbit model. Setting: Harlan Biotech Israel and Ophthalmology Department, Kaplan Medical Center, Rehovot, Israel. Design: Experimental study. Methods: Rabbit eyes were randomly assigned to 3 equally sized groups. Endothelial cell counts were performed in all eyes before initiation of the study. The aqueous humor was completely replaced by Biolon (sodium hyaluronate 1.0%) in Group A, by a combination of Viscoat (sodium chondroitin sulfate 4.0%-sodium hyaluronate 3.0%) and Provisc (sodium chondroitin sulfate 1.0%) using the soft-shell technique in Group B, and by a combination of Visiol (sodium hyaluronate 2.0%-mannitol 0.5%) and Biolon using the soft-shell technique in Group C. The eyes were exposed to alternating 10 seconds of phacoemulsification and a 10-second pause until a total exposure time of 2.5 minutes elapsed. Endothelial cell counts were repeated 3 days after surgery. Results: The study used 18 rabbit eyes, 6 in each group. Group A had the highest endothelial cell loss (13%) followed by Group B (7%), and Group C (4%). The difference in cell loss between Group C and Group A was statistically significant (P = .037). Conclusion: The study showed the efficiency and advantages of the soft-shell technique using the combination of Visiol and Biolon over Biolon alone. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.
UR - http://www.scopus.com/inward/record.url?scp=78049287252&partnerID=8YFLogxK
U2 - 10.1016/j.jcrs.2010.05.023
DO - 10.1016/j.jcrs.2010.05.023
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C2 - 21029907
AN - SCOPUS:78049287252
SN - 0886-3350
VL - 36
SP - 1972
EP - 1975
JO - Journal of Cataract and Refractive Surgery
JF - Journal of Cataract and Refractive Surgery
IS - 11
ER -