Protective desmoplasia in pancreatic adenocarcinoma: High Vitamin D receptor expression and collagen content

Adi Vaknine Bahat, Shoshi Bar-David, Abigail Brooks, Asaf Aizic, Orli Greenberg, Ido Wolf, Joseph M. Klausner, Guy Lahat, Eran Nizri

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: Vitamin D receptor (VDR) has been shown to suppress desmoplasia in pancreatic ductal adenocarcinoma (PDAC). Our aim was to assess the clinical effects of VDR expression and its correlation with collagen content in the desmoplasia of PDAC patients. Patients and Methods: This is a retrospective analysis of 127 patients with peritumoral desmoplasia resected for PDAC. VDR expression and collagen content were assessed by immunohistochemistry and correlated with clinical outcome. Results: Patients were classified into those with high and those with low VDR expression. High VDR expression was associated with improved overall survival (OS) in localized disease (N0) (median= 33; 95%CI=26.4-39.6 vs. 18; 15.5-20.5 months, p=0.01). Patients with high vs. low collagen content had improved OS [34, (range=22.3-45.6 months) vs. 17, (range=14.4-19.6 months), p<0.001]. The number of VDR+ cells was the same for patients with either high or low collagen content. Conclusion: Protective desmoplasia is associated with increased VDR expression and collagen content.

Original languageEnglish
Pages (from-to)6457-6464
Number of pages8
JournalAnticancer Research
Volume40
Issue number11
DOIs
StatePublished - Nov 2020

Keywords

  • Collagen
  • Desmoplasia
  • Pancreatic ductal adenocarcinoma
  • Vitamin D receptor

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