Protection against developmental deficiencies by a lipophilic VIP analogue

Illana Gozes; Michal Bachar; Amos Bardea; Ariane Davidson; Sara Rubinraut; Mati Fridkin

doi:10.1023/A:1022494907001

Protection against developmental deficiencies by a lipophilic VIP analogue

Illana Gozes^*
, Michal Bachar
, Amos Bardea
, Ariane Davidson
, Sara Rubinraut
, Mati Fridkin

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Tel Aviv University
Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Stearyl-Nle-VIP (SNV) is a novel agonist of vasoactive intestinal peptide (VIP) exhibiting a 100-fold greater potency than the parent molecule and specificity for a receptor associated with neuronal survival. Here, the developmental and protective effects of SNV were investigated in vive using two models of developmental retardation, hypoxia and cholinergic blockade. In both cases chronic administration of SNV during development provided protective effects. Water maze experiments on the weaned animals have demonstrated a prophylactic action for SNV and enhancement of spatial memory in animals exposed to a cholinotoxin. SNV may act by providing neuroprotection, thereby improving cognitive functions. This work is dedicated to Prof. R.J. Wurtman whose inspiration and leadership in the field of neuroscience and cognition is beyond comparison.

Original language	English
Pages (from-to)	689-693
Number of pages	5
Journal	Neurochemical Research
Volume	23
Issue number	5
DOIs	https://doi.org/10.1023/A:1022494907001
State	Published - 1998

Keywords

Cholinergic blockade
Developmental milestones
Hypoxia
Learning and memory
Vasoactive intestinal peptide

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10.1023/A:1022494907001

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abstract = "Stearyl-Nle-VIP (SNV) is a novel agonist of vasoactive intestinal peptide (VIP) exhibiting a 100-fold greater potency than the parent molecule and specificity for a receptor associated with neuronal survival. Here, the developmental and protective effects of SNV were investigated in vive using two models of developmental retardation, hypoxia and cholinergic blockade. In both cases chronic administration of SNV during development provided protective effects. Water maze experiments on the weaned animals have demonstrated a prophylactic action for SNV and enhancement of spatial memory in animals exposed to a cholinotoxin. SNV may act by providing neuroprotection, thereby improving cognitive functions. This work is dedicated to Prof. R.J. Wurtman whose inspiration and leadership in the field of neuroscience and cognition is beyond comparison.",

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T1 - Protection against developmental deficiencies by a lipophilic VIP analogue

AU - Gozes, Illana

AU - Bachar, Michal

AU - Bardea, Amos

AU - Davidson, Ariane

AU - Rubinraut, Sara

AU - Fridkin, Mati

PY - 1998

Y1 - 1998

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AB - Stearyl-Nle-VIP (SNV) is a novel agonist of vasoactive intestinal peptide (VIP) exhibiting a 100-fold greater potency than the parent molecule and specificity for a receptor associated with neuronal survival. Here, the developmental and protective effects of SNV were investigated in vive using two models of developmental retardation, hypoxia and cholinergic blockade. In both cases chronic administration of SNV during development provided protective effects. Water maze experiments on the weaned animals have demonstrated a prophylactic action for SNV and enhancement of spatial memory in animals exposed to a cholinotoxin. SNV may act by providing neuroprotection, thereby improving cognitive functions. This work is dedicated to Prof. R.J. Wurtman whose inspiration and leadership in the field of neuroscience and cognition is beyond comparison.

KW - Cholinergic blockade

KW - Developmental milestones

KW - Hypoxia

KW - Learning and memory

KW - Vasoactive intestinal peptide

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Protection against developmental deficiencies by a lipophilic VIP analogue

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