TY - JOUR
T1 - Protection against developmental deficiencies by a lipophilic VIP analogue
AU - Gozes, Illana
AU - Bachar, Michal
AU - Bardea, Amos
AU - Davidson, Ariane
AU - Rubinraut, Sara
AU - Fridkin, Mati
PY - 1998
Y1 - 1998
N2 - Stearyl-Nle-VIP (SNV) is a novel agonist of vasoactive intestinal peptide (VIP) exhibiting a 100-fold greater potency than the parent molecule and specificity for a receptor associated with neuronal survival. Here, the developmental and protective effects of SNV were investigated in vive using two models of developmental retardation, hypoxia and cholinergic blockade. In both cases chronic administration of SNV during development provided protective effects. Water maze experiments on the weaned animals have demonstrated a prophylactic action for SNV and enhancement of spatial memory in animals exposed to a cholinotoxin. SNV may act by providing neuroprotection, thereby improving cognitive functions. This work is dedicated to Prof. R.J. Wurtman whose inspiration and leadership in the field of neuroscience and cognition is beyond comparison.
AB - Stearyl-Nle-VIP (SNV) is a novel agonist of vasoactive intestinal peptide (VIP) exhibiting a 100-fold greater potency than the parent molecule and specificity for a receptor associated with neuronal survival. Here, the developmental and protective effects of SNV were investigated in vive using two models of developmental retardation, hypoxia and cholinergic blockade. In both cases chronic administration of SNV during development provided protective effects. Water maze experiments on the weaned animals have demonstrated a prophylactic action for SNV and enhancement of spatial memory in animals exposed to a cholinotoxin. SNV may act by providing neuroprotection, thereby improving cognitive functions. This work is dedicated to Prof. R.J. Wurtman whose inspiration and leadership in the field of neuroscience and cognition is beyond comparison.
KW - Cholinergic blockade
KW - Developmental milestones
KW - Hypoxia
KW - Learning and memory
KW - Vasoactive intestinal peptide
UR - http://www.scopus.com/inward/record.url?scp=0031921669&partnerID=8YFLogxK
U2 - 10.1023/A:1022494907001
DO - 10.1023/A:1022494907001
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AN - SCOPUS:0031921669
SN - 0364-3190
VL - 23
SP - 689
EP - 693
JO - Neurochemical Research
JF - Neurochemical Research
IS - 5
ER -