Proteasome channel opening as a rate-limiting step in the ubiquitin-proteasome system

Keyphrases

• Rate-limiting Step 100%
• Ubiquitin-proteasome System 100%
• Channel Opening 100%
• ER-associated Degradation 100%
• Open Channel 50%
• Performance Improvement 25%
• Mild Stress 25%
• Secretory Pathway 25%
• Double mutant 25%
• Protease 25%
• Stress Conditions 25%
• Overall Rate 25%
• Multi-step Process 25%
• Active Sites 25%
• Membrane Substrate 25%
• Proteolytic Cascade 25%
• Catalytic Core 25%
• Cytosolic Proteins 25%
• Rate Limiting 25%
• High-temperature Performance 25%
• Catalyst Particle 25%
• Hydrolysis Rate 25%
• 26S Proteasome 25%
• Central Channel 25%
• 20S Core Particle 25%
• Rule Fusion 25%
• Peptidase Activity 25%
• Classical mutant 25%
• N-end Rule 25%
• Core Particle 25%
• Regulatory Particle 25%
• Gating Pore 25%
• Ubiquitin Fusion 25%
• Peptide Hydrolysis 25%

Biochemistry, Genetics and Molecular Biology

• Ubiquitin 100%
• Proteasome 100%
• Endoplasmic Reticulum Associated Degradation 57%
• N-Terminus 28%
• Enzymatic Hydrolysis 14%
• Active Site 14%
• Secretory Pathway 14%
• Peptidase 14%
• N-End Rule 14%
• Protease 14%